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1.Each year, ∼47% of the population experience headache, including migraine, tension-type headache, and chronic daily headache.
2 A sexual dimorphism exists for headache disorders, with women 2-3 times more likely to experience migraine3 and 1.25 times more likely to experience tension-type headache than men.4 The present review will focus largely on migraine, tension-type headache, trigeminal autonomic cephalalgias, and medication-overuse headache.
12,13 Treatment depends on the underlying headache condition; however, some popular options include NSAIDs for mild headaches and triptans, anti-depressants, verapamil, or ergotamine for more severe or chronic headaches.
Search keywords included cannabis; cannabinoids; headache; migraine; cluster headache; medication-overuse headache; tetrahydrocannabinol; cannabidiol; clinical trial; placebo; and double blind.
Historical Reports of the Use of Cannabis as a Treatment for Headache Early reports of cannabis for the treatment of headache appear to be largely positive, with many patients experiencing a decrease in the frequency and intensity of their headache episodes.
Studies on the Role of Cannabinoids in Headache Pathogenesis Underlying cause of headaches Various genetic factors can predispose individuals to migraines.
Vasodilation is not necessarily pathogenic for headaches, and endocannabinoid-induced vasodilation could desensitize the vasculature to known headache progenitors, such as NO. Interestingly, NO appears to also exert nociceptive effects through FAAH, as deletion of an FAAH inhibitor or addition of an FAAH inhibitor prevents nociceptive reaction to NO.78 One could postulate a possible feedback effect wherein NO and FAAH overpower endocannabinoids to illicit pain.
Go to: Conclusion The present review examines the historical guidelines for cannabis treatment of headache, available clinical data on the use of cannabis for headache, and preclinical literature on the role of the endocannabinoid system in headache pathophysiology.
Evans RW, Ramadan NM. Are cannabis-based chemicals helpful in headache? Headache.The-Use-of-Cannabis-for-Headache-Disorders-Cannabis-Research-for-Headaches-and-Migraines- (1)