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New Perspectives in the Studies on Endocannabinoid and Cannabis: Abnormal Behaviors Associate With CB1 Cannabinoid Receptor and Development of Therapeutic Application
Cannabinoids are a collection of compounds that are situated in the marijuana plant (cannabis sativa). Cannabidiol (CBD) is the main chemical within the cannabis plant and it is said by the wide scientific community that it has anti inflammatory effects when induced into animal cells. Tetrahydrocannabinol (THC) is another one of these chemicals and it is said to have a psychotropic effect. Cannabinoid receptors (CB1 and CB2) are located in the endocannabinoid system and gives cannabinoids power to bind and thrive in the body. This paper will outline how cannabinoids work in the body as a therapeutic agent.
THC has a psychoactive effect
Tetrahydrocannabinol, the main psychoactive component of cannabis impairs the spatial memory in rats. These abnormal behaviors could be treated by SR141716A, a CB1 cannabinoid receptor antagonist. On the other hand, THC actually inhibits the neurodegeneration in experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis and decreased the heightened glutamate level of cerebrospinal fluid induced by EAE. These analgesic effects on EAE were reversed by SR141716A. Taken together, these conclusions show that the inhibition of glutamate release via activation of the CB1-cannabinoid receptor is one mechanism involved in 9 THC-induced impairment of spatial memory in rats.The analgesic impact of THC on EAE might give an efficient treatment for psychosis and neurodegenerative diseases.
THC might be a therapeutic agent
This study shows that THC may impair spatial memory in rats by inhibiting glutamate release through the CB1 cannabinoid receptor. Also it is said THC induces abnormal behaviors such immobilization and aggressive behavior through the CB1 cannabinoid receptor. Overall, it is said that cannabinoid receptor agonists can be developed into therapeutic agents because of their anti inflammatory effects in rats.96_362