Therapeutic Potential of the Endocannabinoid System | cannabisMD

Therapeutic Potential of the Endocannabinoid System

Therapeutic Potential of the Endocannabinoid System; Cell Press

Cell Press

The Therapeutic Potential of the Endocannabinoid System for the Development of a Novel Class of Antidepressants

Cannabinoids are a group of chemicals that come from the cannabis plant (cannabis sativa). Cannabidiol (CBD) is one of these chemicals and studies have suggest that it has anti inflammatory effects when induced in animals. Tetrahydrocannabinol (THC) is another one of these compounds that wields a psychotropic effect in animals. Cannabinoid receptors (CB1 and CB2) are found in the endocannabinoid system and allow cannabinoids to bind and do their job in the body. This paper will look at how the endocannabinoid system should be a target for cannabinoids that are therapeutic to people with depression.

Main Points

  • Endocannabinoid system regulates cognitive processes
  • Cannabinoids may be therapeutic to people with depression

Endocannabinoid system regulates cognitive processes

The endocannabinoid system is a neuro altering system which is said to control emotional, cognitive, neurovegetative and motivational actions. Hug research has amounted implicating a decrease in endocannabinoid levels during depression; accordingly, pharmacological wielding of endocannabinoid transmissioning could be a good target for the pharmacotherapy of depression. In tests, functioning of endocannabinoid neural signalling make both antidepressant and anxiolytic impacts. Similar to the abilities of normal antidepressants, increasing of endocannabinoid transmissioning can increase serotonergic and noradrenergic signalling; greater the amount of cellular plasticity and neurotrophin expression inside the hippocampus; and dampen actions within the neuroendocrine stress related receptors in the brain. More so, limbic endocannabinoid activity is greatered by both pharmacological and somatic therapeutics for depression, and, in turn, looks like it helps neuroadaptive changes evoked by these therapeutics. These tests support the idea for the clinical advancement of drugs which induce the cellular uptake and metabolism of endocannabinoids in the producing of therapeutics for mood syndromes.

Cannabinoids may be therapeutic to people with depression

The endocannabinoid system is in abundance around the corticolimbic circuits in the brain that is impacted during the treatment of depressive disorder. Impairments in endocannabinoid transmissioning make behavioral disturbances look familiar like the the sign clusters related with depression and both rodent models of depression and human patients that have great depression show hypoactive endocannabinoid transmissioning. On the other hand, wielding of endocannabinoid signaling gives off antidepressant and anxiolytic-like behavioral actions in rodent models. Similarly, numerous pharmacological and somatic treatment disciplines for depression better the endocannabinoid neural signalling system and, in some times, this increase is needed for the neurobiological adaptations made possible by these treatments.

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