Cannabinoids come in different forms i.e. from humans (endo), plants (phyto) and labs (synthetic). The cannabinoids we mention most often at cannabisMD are human cannabinoids such as 2-Arachidonoylglycerol (2-AG) and plant based cannabinoids like CBD (cannabidiol), THC (Tetrahydrocannabinol) and CBN (cannabinol). Although discovered a number of years ago it is recent research that is only now discovering how these cannabinoids work, for better or worse.
CBD is considered the anti-inflammatory cannabinoid although it has been recorded as having other properties within the brain. THC, as we all know is the “get high” cannabinoid known for its neurological properties. CBN is a lesser known cannabinoid but it would appear it certain circumstances this cannabinoid can provide the potential benefits of both CBD & THC with out any negative side effects.
The discovery on the endocannabiniod system (ECS) is what has made this research possible to date. Every human and all animals (other any insets) have an ECS. Which plays a vital role in regulating or key organs and bodily functions.
This review will give evidence in the context of cannabinoids therapeutic potential and how they work in the endocannabinoid signaling system.
Here is the full scientific article if you wish to download it.
Cannabinoids promote a lot of biological impacts, including the alteration of neuronal activity through the triggering of CB1 receptors and of immune responses through the triggering of CB2 receptors. The specific targeting of either of these two receptor kinds has clear therapeutic value.
Recent studies have demonstrated that some of the synthetic cannabinoid effects previously thought to be produced through CB1 and/or CB2 receptors, still persist despite the pharmacological blockade or genetic ablation of CB1 and/or CB2 receptors. This study hints that additional cannabinoid and cannabinoid-like receptors exist.
In summary, evidence indicates that cannabinoid receptors are triggered by chemically and structurally similar lipids and are induced in the same biological processes, point at the possibility that these signaling patterns may mix with the receptor or signal transduction levels.
These two receptors are a potentially efficiently regulatory key for biological processes, and thus may promote a novel target for therapeutic approaches. Overall, this study provides good evidence for different types of cannabinoids in medical marijuana to have positive health effects when treating chronic pain.