Cannabinoids are chemical compounds that are naturally occurring in the cannabis plant (cannabis sativa). Cannabidiol (CBD) is one of these chemicals. Studies have shown it has anti-inflammatory effects when induced on animal cells. People have smoked the marijuana plant for thousands of years and it has said have an anti-inflammatory role in the body which in turn helps the immune system
Tetrahydrocannabinol (THC) is another one of these chemicals and it is said it has psychoactive effects. Major cannabinoid receptors (CB1 and CB2) are found in the endocannabinoid system and allow exogenous and endogenous cannabinoids to thrive in the body. This paper will look at how synthetic cannabinoids, spice/K2, can be bad for users and how natural cannabinoids can be beneficial in the treatment of synthetic cannabinoid addiction.
Here is the full scientific article if you wish to download it.
Synthetic cannabinoids in forms such as hold a relatively new class of designer substances that have recently surfaced as popular sidekicks to cannabis otherwise described as “legal highs”. These substances are readily available on the world wide web and sold in many head shops and supermarkets behind the mask of innocuous products like herbal mixtures, incense, or air fresheners.
Although package labels suggest “not for human use”, the number of intoxicated people coming to A&E is on the rise. The lack of validated and standardized human testing methods and an endless cache of potential substances of abuse are the main reasons why scientists find it hard to fully describe clinical consequences related to Spice.
While the exact compound composition and toxicology of Spice remains to be seen, there is increasing evidence identifying several synthetic cannabinoids as causative drugs that are the reason for psychoactive and adverse events. This study gives updates on the legal status of common synthetic cannabinoids found in Spice and analytical methods applied to assess Spice products and human specimens gained under numerous clinical circumstances. The pharmacological and toxicological risks of synthetic cannabinoid abuse are also evaluated to give a future perspective on possible short- and long-term implications.
Since most synthetic cannabinoids are not now discovered applying routine toxicology screening assessments, health care providers, especially those functioning in emergency care situations, should be constantly on alert for K2 drug-induced toxicity despite bad drug-screening conclusions. Very little data is now at the ready on the pharmacodynamics and pharmacokinetics of synthetic cannabinoids. While the thought is popular that most Spice drugs are potent CB1 agonists, exact molecular actions underlying their toxic impacts remain to be seen.
These chemicals and their metabolites have been discovered to hold greater binding properties for cannabinoid receptors than cannabis, which advocates greater potency, greater side effects, and perhaps a longer duration of action. Overall, it can be said that cannabis can be beneficial to synthetic cannabis users in that it can naturally restore the body’s endogenous cannabinoids to their normal state.
Synthetic cannabis should not be smoked and should only be administered by doctors who know how to use it. Overuse of synthetic plant cannabinoids can lead to personality disorders, bipolar disorders, mood disorders and other mental illness.