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Evaluation of WIN 55,212-2 self-administration in rats as a potential cannabinoid abuse liability model
A cannabinoid is one of a great collection of complex chemical compounds that operates on cannabinoid receptors in cells that fluxuates neurotransmitter release in the brain. Cannabinoids for these receptors include the endocannabinoids, that are made naturally in the body by animals, the phytocannabinoids in cannabis and some other plants, and synthetic cannabinoids. The main cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive chemical in cannabis. Cannabidiol (CBD) is another main constituent of the plant and produces a non psychotic effect. The researchers in this study aimed to evaluate a possible synthetic cannabinoid abuse in rats.
THC may be problematic as it is seen to be addictive
The evaluation of the addictive potential of selective cannabinoid medications has been deemed hard. Researchers have found out how to train rats how to self administer synthetic cannabinoids. In this study, rats were trained to self-administer a selective synthetic cannabinoid and the effects of CB1 receptor antagonisation was evaluated. While this study gives systematic replication of previous research, lack of substitution with THC is problematic and indicates that the selective synthetic cannabinoid self-administration might be of limited benefit as a screening tool for checking the responding impacts of potential cannabinoid prescriptions. Transparency of underlying risks responsible for unsuccess of THC to hold up self-administration in cannabinoid-trained rats is required.
Additional research is needed on synthetic cannabinoid abuse in rats
Overall, successful self-administration of synthetic cannabinoid, WIN55,212-2, was held over the duration of this research. Substitution of other doses of this synthetic cannabinoid made an inverted U-shaped dose-impact function which looked like that received with cocaine in rats trained to self-administer this stimulant. Rimonabant dose-dependently attenuated the amount of infusions of the synthetic cannabinoid training dose, indicating CB1 receptor controlling of the synthetic cannabinoids reinforcing impacts. On the other hand, the part time agonist THC stopped the maintenance of self-administration above vehicle levels in the synthetic cannabinoid trained rats. While cannabinoid self-administration in rats has been used rightfully to test risks that may affect the incoming impacts of cannabinoids, it now has limited usefulness as a screening procedure for assessment of cannabinoid addiction liability in the medication advancement course. Additional research is needed in this field of studynihms555118-1