A 21 patient study found that the use of a cream which had structured physiologic lipids along with endogenous cannabinoids was beneficial for 8 of the patients. The cream was applied twice daily for 3 weeks and was found to completely get rid of pruritus, but what is pruritus?
Uraemic Pruritus: This is a serious issue that happens when both kidneys fail to work properly and it is also known as chronic kidney pruritus (CKD-associated pruritus) as a result. Uraemia is the part of the issue which relates to blood flow. When Uraemic Pruritus happens there is an increase in the amount of urea within the blood due to the kidney failure. This then causes common symptoms we experience in regards to dermatology such as itching (pruritus).
Here is the full scientific article if you wish to download it.
In relation to the treatment mentioned within the study, it should be pointed out that it was applied during dialysis. Therefore although the cream treatment helped with the dermatologic aspect of the kidney failure the cream did not have an effect on the kidneys. This shows how such a cannabinoid treatment could be successfully used along side other modern treatments for a more conclusive treatment for all symptoms of uraemic pruritus.
Uraemic Pruritus Cream Treatment: The cream used within the study included organic compounds known as physiologic lipids which range from healthy fats, steroids, vitamins which are useful for binding with proteins and carbohydrates. These bonded proteins create lipopolysaccharides (LPS) and lipoproteins which are useful for looking after good forms of bacteria and protecting our bodies especially our livers from bad bacteria.
Other treatments researched within the study include palmitoylethanolamide and a cannabis based cream. Palmitoylethanolamide (PEA), which stimulates anandamide activation of cannabinoid 1 receptors, reduced itch by 86.4% and was well tolerated by patients. The cannabis cream included a small amount (3%) of cannabis seed extract and was used to treat seborrheic dermatitis and acne. Patients found a decrease in the levels of sebum and erythema.
A protein called the WIN 55,212-2, protein is a cannabinoid agonist which means it causes cannabinoids to react in certain ways increase/decrease. It has also been found to act in a similar way to THC (Tetrahydrocannabinol) although it has a different chemical structure.
In this case it was discovered to reduce the amount of serotonin which in turn also reduced the amount of itching experienced by model mice. These studies identify a relationship between cannabinoids and the immune system through both receptor-mediated and receptor-independent pathways.
As mentioned before it is known from different studies that cannabinoids have useful properties for the treatment of acne based symptoms but they also have an overall use for dermatitis too. We understand that both THC and PEA have uses in treating different skin related issues. We have provided a list of cannabinoids and their potential medical uses below.
|Palmitoylethanolamide (PEA)||Pruritus, Allergic contact dermatitis, Atopic Dermatitis, Other Eczematous, Dermatoses, Melanoma|
|Tetrahydrocannabinol (THC) Psychotropic||Allergic contact dermatitis, Psoriasis, Melanoma|
|Tetrahydrocannabinol (THC) Psychotropic||Psoriasis|