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Pharmacology and potential therapeutic uses of cannabis
Cannabinoids are derived from the cannabis plant (cannabis sativa). Studies have found that these cannabinoids are effective in pain management. They have said to treat ailments of chronic pain such as:
A cannabinoid is one of a great collection of complex chemical compounds that naturally occur in the body and operates on major cannabinoid receptors in cells that mediates neurotransmitter release in the brain.
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Endogenous cannabinoids for these receptors include the endocannabinoid system, that is produced in the body by animals, the phytocannabinoids in cannabis and some other plants, and synthetic cannabinoids. The main cannabinoid is the plant cannabinoid tetrahydrocannabinol (THC), the primary psychoactive chemical in cannabis. Cannabidiol (CBD) is another main constituent of the plant and produces a non-psychotic effect.
Throughout the past, marijuana has been applied as a natural soothing solution. In Fact, the findings of the bones of a small girl in Jerusalem who passed away at childbirth around about the third century AD displayed remnants of marijuana in the pelvic region. This potently indicates that cannabis was applied in medical situations in early human civilizations. Marijuana was first applied as a medicine in Britain in the mid-nineteenth century by O’Shaugnessy, a military surgeon.
While on an expedition to India O’Shaugnessy seen at first hand the appliance of marijuana for a wide range of medical disorders such as rabies, epilepsy and muscle stiffness, and for pain relief. On his return to Britain, O’Shaugnessy suggested its appliance and marijuana was widely accepted as a medicine for about 70 years. This paper has evaluated the pharmacology of cannabinoids and their therapeutic plausibility. Specifically, researchers here will talk about their use as antinociceptive/ therapeutic agents.
A puzzling image of the physiology and pharmacology of cannabinoids is coming out of the woodwork. Both a central and peripheral receptor have been replicated and presumed endogenous agonists discovered. The pharmaceutical industry has provided researchers with a wide selection of apparatus to spur on the cannabinoid system, and antagonists for both types of the receptor are ready.
Suggestions from recreational marijuana smokers, together with case studies, anecdotal reports, a few limited clinical experiments and animal function, indicate massive analgesic plausibility for cannabinoids. Clinical studies into cannabinoids are in its larval stages, and current information gives no more than suggestions for further research. Nabilone is not likely to be the best drug and it may be that mixtures of natural cannabinoids and tests of different paths of dosing offer the best chance of gaining the therapeutic effects.