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Different Classes of CB2 Ligands Potentially Useful in the Treatment of Pain
Cannabinoids are found in the marijuana plant (cannabis sativa) and are said to be effective in pain management from pain symptoms such as multiple sclerosis and nausea and vomiting. A cannabinoid is one of a great collection of complex chemical compounds that naturally occur in the body and operates on major cannabinoid receptors in cells that mediates neurotransmitter release in the brain. Classes of cannabinoids for these receptors include the endocannabinoid system, that are produced in the body by animals, the phytocannabinoids in cannabis and some other plants, and synthetic cannabinoids. The main endogenous cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive chemical in cannabis. Cannabidiol (CBD) is another main constituent of the plant and produces a non psychotic effect. Cannabinoids have a therapeutic potential no doubt, however they are yet to be studied in depth to treat a wide range of human pathologies. This paper will look at cannabinoids potential to be used in the treatment of chronic pain.
Cannabinoids could be useful in the treatment of inflammation
The discovery of new agents and targets to cure the pain is an interesting feat both for numerous firms and researchers from academia. In this regard, since the changing of the endocannabinoid network with the non specific plant cannabinoid THC gives off therapeutic effects and potentiates opioid analgesia in animal experiments, cannabinoid receptor 2 cannabinoid research sets its aims to delve into the world of the endocannabinoids network in the regulation of pain. Numerous specific cannabinoids 2 receptor agonists showed therapeutic abilities in preclinical experiments of acute, inflammatory and neuropathic types of pain, therefore this group of alternators could be applicable as therapeutic drugs for pain, migraine, inflammation and osteoarthritis. This paper is an update of a previous manuscript “A survey of recent patents on CB2 agonists in the management of pain” and gives an evaluation of patents and developments in CB2 agonist research in the treatment of pain. Overall, cannabinoids can be a useful anti inflammatory in the treatment for acute pain and painful conditions.
Cannabinoids have a therapeutic utility
The large portion of filed and allowed patents on cannabinoid 2 receptor alternators with specific reference to the curing of pain by contrasting companies and research classes from academia, is a suggestion of the continuous intrigue to the identification of CB2 receptor agonists as plausible therapeutic agent chosen for the pharmaceutical industry; however, nowadays no cannabinoid 2 receptor agonists have been advertised for the treatment of pain. In this paper, researchers have selected and updated current patents that highlight on new advancements in the cannabinoid 2 receptor field, specifically focusing on those views which deal with their use in the curing of pain. From these patents it is plausible to single out some chemicals which hold high affinity and selectivity for cannabinoid 2 receptors on cannabinoid 1 receptors, together with great oral bioavailability and good metabolic comfort. Numerous specific cannabinoid 2 receptor agonists displayed therapeutic effects in different preclinical models of acute, inflammatory and neuropathic pain; therefore these chemicals could be applicable tools to test the biological risks of cannabinoid 2 receptor triggering in animals. Further, even if the method and site of action in cahoots with cannabinoid 2 controlled therapeutic effect remain unexplained, the analgesic utility of specific cannabinoid 2 agonists as applicable therapeutic agents for numerous kinds of pain, will be evaluated through their review in human clinical experiments as this represents valuable information needed for a a final answer regarding their effectiveness in the regulation of pain.Different-classes-of-CB2-ligands-in-Pain