A cannabinoid is one of a collection of complex chemical compounds that operates on cannabinoid receptors in cells that fluxuates neurotransmitter release in the brain. Cannabinoids for these receptors include the endocannabinoids, that are made naturally in the body by animals, the phytocannabinoids in cannabis and some other plants, and synthetic cannabinoids. The main cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive chemical in cannabis. Cannabidiol (CBD) is another main constituent of the plant and produces a non psychotic effect. This paper will look at how oral THC and oromucosal cannabis extract can be administered and how it works in the body.
Here is the full scientific article if you wish to download it.
CBD can alleviate the effects of THC
Sativex, a cannabis extract oromucosal spray that contains THC and CBD, is now in advanced trials as a substitute to opioids for a cancer pain therapeutic, and recently seen the United Kingdom give it’s go ahead for treatment of muscle stiffness. There are suggestions that CBD changes THC’s impacts, but it is not transparent if this is due to a pharmacokinetic/pharmacodynamic relationship. Marijuana users gave permission to take part in the study and these participants got given 5 and 15 mg synthetic oral THC, a low dose of CBD and a high-dose of Sativex. Nine marijuana users accomplished all 5 dosing meetings. Colossal discrepancies in the blood were discovered between low and high administrations of synthetic THC and Sativex. These results indicate that CBD modulation of THC’s impacts is not due to a pharmacokinetic relationship at these treatment doses.
Sativex and THC have therapeutic benefits
A number of benefits lay awake for oromucosal marijuana plant extracts over single oral synthetic cannabinoids. An alloy of cannabinoids and residing plant chemicals give additional therapeutic possibilities for treating a variety of medical conditions. Oromucosal doses also are more wanted than the oral road for treating nausea and for increasing appetite. More so, self-titration often is needed in this population to regulate pain and muscle stiffness, and to relieve unwanted subjective impacts. This study has presented, for the very first time, a comparison between the pharmacokinetics of 2 oral THC and 2 Sativex. These results will improve interpretation of CBD, THC, and metabolite doses. There were no clinically huge pharmacokinetic contrasts between Sativex and oral administration of parallel THC doses in this preliminary research, indicating that changes of THC’s physiological or behavioral impacts is not due to a pharmacokinetic relationship.