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Cannabis plant contains more than 400 chemical compounds, of which about 80 chemicals are unique for the plant. Cannabinoids bind to their specific receptors in the body, CB1 and CB2, in order to exert their actions. The most psychotropic plant-derived component (which affects the mental activity, mood, and perception) in cannabis plant is tetrahydrocannabinol (THC) which has several therapeutic benefits. However, THC induces remarkable side effects related to the psychiatric and behavioral health. Other non-psychotropic plant cannabinoids may act efficiently in the body with a safer mechanism that yields minimal side effects. Such cannabinoids include cannabidiol (CBD), cannabigerol(CBG), cannabichromene (CBC), and tetrahydrocannabivarin (THCV). Given that these compounds have attracted the attention of the researchers for their diverse therapeutic potential, this study reviewed the role of non-psychotropic plant cannabinoids therapy in the body.
Here is the full scientific article if you wish to download it.
Studies have shown that CBD can be used to manage psychosis effectively. Additionally, its administration was associated with fewer adverse effects when compared to other anti-psychotic medications. According to the experimental studies, CBD and THCV have the ability to reduce the frequency of epileptic seizures by inhibiting nerve excitation. CBD was also effective in the prevention of anxiety and it may help induce sleep in rats although it may have some alerting properties.
Due to its excellent antioxidant effects, CBD have good effects on a wide range of pathophysiological processes involved in the development of Alzheimer’s disease and Parkinson’s disease. These effects are specifically attributable to the protective role of CBD on the nerves. For the disorders that cause reduced blood supply to the brain (cerebral ischemia), CBD have the ability to reverse brain damage. In comparison to THC, the effects of CBD can last for longer time, it is not dependent on cannabinoid receptors, and is not associated with a reduced action with repeated use.
Miscellaneous therapeutic applications
CBD is also effective for a range of diseases which are characterized by attacking the body cells by the own immune system. This is due to the anti-inflammatory and immunosuppressive actions. The anti-inflammatory and anti-oxidant properties of CBD enabled it to exert considerable effects against diabetes in its initial or late stages as well as some diabetic complications, such as those occurring in the retina. For the gastrointestinal system, CBD is currently used as a potent medication to prevent nausea and vomiting in chemotherapy-receiving patients. Importantly, the experimental data revealed that CBD can inhibit the growth and proliferation of cancer cells in brain and breast tumors and leukemia. This action was observed due to its selective effect on cancer cells to cause their death. Other plant-derived cannabinoids, including THCV and CBG, are effective in stimulation of bone formation during the process of fracture healing.
Non-psychotropic plant cannabinoids therapy is effective in a wide range of diseases that involve the nervous, cardiovascular, skeletal, immune systems. CBS is extensively studies for their promising actions showing an extremely safe profile. Future studies are warranted to investigate the effects of other cannabinoids, including a comprehensive interpretation and comparison of their results to CBD actions.