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The case for medical marijuana in epilepsy
Cannabinoids are found in the marijuana plant (cannabis sativa) and are said to be effective in pain management from pain symptoms such as multiple sclerosis and nausea and vomiting. A cannabinoid is one of a great collection of complex chemical compounds that naturally occur in the body and operates on major cannabinoid receptors in cells that mediates neurotransmitter release in the brain. Cannabinoids for these receptors include the endocannabinoid system, that are produced in the body by animals, the phytocannabinoids in cannabis and some other plants, and synthetic cannabinoids. The main endogenous cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive chemical in cannabis. Cannabidiol (CBD) is another main constituent of the plant and produces a non psychotic effect. Cannabinoids have a therapeutic potential no doubt, however they are yet to be studied in depth to treat a wide range of human pathologies. This paper will look at how medical marijuana can treat seizures arising from epilepsy in humans.
Cannabinoids may hold antiepileptic mechanisms
Charlotte, a young woman with SCN1A‐confirmed Dravet disorder, was recently shown in a special on the television network CNN. Through tiresome personal studies and hands lent from a Colorado‐based medical cannabis association (Realm of Caring), Charlotte’s mom began additional treatment with a potent THC and CBD strain of marijuana, now described as Charlotte’s Web. This paper slowly hashed out over months and provided in cahoots with her existing antiepileptic drug schedule, decreases Charlotte’s seizure frequency from nearly 50 convulsive seizures per day to now 2–3 nocturnal seizures per month. This impact has lasted for the past 20 months, and Charlotte has been beneficially taken from her other antiepileptic substances. This paper has evaluated some of the history, preclinical and clinical data, and controversies shrouding the application of medical cannabis for the treatment of epilepsy, and make a suggestion that the want to single out and treat with pharmaceutical grade chemicals from marijuana specifically CBD may be better than therapy with whole plant extracts. Much more needs to be known about the methods of the antiepileptic work of the plant cannabinoids and other chemicals of Cannabis sativa.
Cannabinoids may have a therapeutic ability
Despite all of the setbacks of medical cannabis as a plausible therapy for epilepsy, what is not controversial is the requirement or a call for calm, and at the same time a call for mindful and in depth pharmacologic and clinical investigation into marijuana and its many particle compounds to disclose or not agree on its security and antiepileptic plausibility. Developers and mediators must satisfy concerns about consistency, quality, and security before medical marijuana will ever receive legitimacy as a mainstream therapeutic option. Overall, Cannabis will be a top player when it comes to acting as a therapeutic for people with epilepsy and it is now up to the government to make it happen.Maa_et_al-2014-Epilepsia