A disturbance of the delicate balance may allow for developments of various diseases within the skin and other pathological conditions. The article emphasis on the physiological regulatory function of the endocannabinoid system in differentiation, apoptosis, cytokine, mediator, hormone production, and proliferation of different cell types of the skin and appendage.
Other than this, evidence of the supposed association of the ECS (the endocannabinoid system) – a newly discovered system, in some pathological conditions of the skin, which include cutaneous itch and pain, neoplastic cell growth, and allergic dermatitis, is assessed.
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To therapeutically see ECS regarding management of a variety of skin diseases, upcoming preclinical and clinical research and is also envisioned. Together, it is recognized that the significant physiological purpose of the cutaneous ECS is to permanently organize the proportionate and manage differentiation, survival, and proliferation along with unaffected proficiency and/or tolerance of the cells of the skin.
The study discusses the endocannabinoid system (ECS) and identifying cannabinoid receptors (CB1 and CB2) and their interaction with the skin. This is because CB receptors have triggered a growth in studies which are exploring the continuously growing regulatory functions in disease and health.
Pathological modifications in the working of the nearly perfect cutaneous ECS may encourage or allow for the growth of some conditions of the skin. Emphasizing on the cutaneous ECS for therapeutic advantage is believed to be an exciting yet challenging prospect allowing for future research.
Through the study, it notes that the ECS functions may have controlled the proper and well-balanced proliferation of skin cells. Target manipulation of the endocannabinoid system (ECS) might normalize skin growth, unwanted skin growth, skin inflammation, and sebum production which in turn might fight acne. However, more in-depth studies are needed, as this study only scratches the surface of the ECS and cannabinoids.