Endogenous Cannabinoid System and it's Role in Treating Epilepsy | cannabisMD

Endogenous Cannabinoid System and it’s Role in Treating Epilepsy

Endogenous Cannabinoid System and it's Role in Treating Epilepsy; ASPET


Cannabinoids are a group of chemical compounds that come from the cannabis plant (cannabis sativa). Cannabidiol (CBD) is one of these chemicals and studies have suggest that it has anti inflammatory effects when induced in animals. Tetrahydrocannabinol (THC) is another one of these compounds that wields a psychotropic effect in animals. Cannabinoid receptors (CB1 and CB2) are found in the endocannabinoid system and allow cannabinoids to bind and do their job in the body. This paper will look at how the endocannabinoid system regulates seizure frequency and how cannabinoids can be used to treat different types of epilepsy.

Here is the full scientific article if you wish to download it.

Main Points

  • Cannabinoids may anticonvulsant properties
  • Therapeutic value of cannabinoids

Cannabinoids may anticonvulsant properties

Several lines of studies point at that cannabinoid chemicals are anticonvulsant. However, the anticonvulsant value of cannabinoids and, more so, the role of the endogenous cannabinoid system in controlling seizures has not been studied in a model of focal epilepsy that is described by sporadic, and frequent types of seizures. In this study, THC is shown to completely prevent epileptic seizures in rats with epilepsy. However, this is in confliction with the application of a cannabinoid CB1 receptor (CB1) antagonist and it was seen to massively increase both seizure duration and frequency. In some animals, CB1 receptor antagonism concluded in seizure durations that were seemed to a level consistent with the clinical syndrome, epilepsy. More so, it is shown that during a short-term seizure, levels of the endogenous cannabinoids increased hugely within the hippocampal part of the brain. These results suggest that anticonvulsant activity of exogenously induced cannabinoids but also indicates that endogenous cannabinoids alter seizure duration through the triggering of the CB1 receptor.

Therapeutic value of cannabinoids

Seizures in people with epilepsy can be hard to mediate despite the use of now available anticonvulsant prescriptions and surgical interventions. Therefore, there is a definite requirement for the development of more efficient anticonvulsant agents. Some epileptics, seeking different treatments, have gotten better with marijuana use. This has made several countries to look at legalizing marijuana for epilepsy treatment. This study represents a refractory epileptic condition that is not readily treated by normal anticonvulsants. This study concludes that the triggering of the CB1 receptor by cannabinoid medications and potentially endogenous cannabinoids massively changes seizure activity and is more efficient than normal anticonvulsants in treating the refractory seizures produced in this studies model. These results are promising as children with epilepsy that have received brain damage can be treated with the marijuana plant with little side effects.

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