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Cancer Cachexia: Traditional Therapies and Novel Molecular Mechanism-Based Approaches to Treatment
Cannabinoids are a collection of compounds that are situated in the marijuana plant (cannabis sativa). Cannabidiol (CBD) is the main chemical within the cannabis plant and it is said by the wide scientific community that it has anti inflammatory effects when induced into animal cells. Tetrahydrocannabinol (THC) is another one of these chemicals and it is said to have a psychotropic effect. Cannabinoid receptors (CB1 and CB2) are located in the endocannabinoid system and gives cannabinoids power to bind and thrive in the body. This paper will outline how cannabinoids work in the body to treat cancer and what the possible future uses of cannabinoid products are in cancer treatment therapy.
Cannabinoids can have a therapeutic effect in people with cancer
The complex disorder of cancer cachexia (CC) occurs in up to 80% cancer patients and it has been discovered that with this comes a greater risk of treatment failure and toxicity, relating to the mortality and morbidity in this people with CC. The most prominent part of CC is its non-responsiveness to normal prescription treatment techniques. In a study of people taking appetite stimulants, 5-HT3 antagonists, nutrient supplementation, and Cox-2 inhibitors, everyone failed to show success in reversing the metabolic disorder seen in CC.
Synthetic Cannabinoids can enhance appetite and mood in cancer patients
Other common drugs include Dronabinol, a synthetic cannabis derivative, seemed to enhance appetite and mood in people with cancer. Although the efficiency as an appetite enhancer has been reviewed in the AIDS disease, the pharmacokinetics of this drug in cancer patients on active treatment has never been reviewed. In addition, because of the psychotropic adverse events, dizziness, dysphoria, depression, hallucinations, alteration in psychomotor function and paranoia, are likely. In spite of the little data on the effectiveness of cannabinoids to better underlying metabolic abnormalities seen in CC, scientists find it possibly useful for treatment in palliative care to better appetite in cancer patients with anorexia.10.10072Fs11864-010-0127-z