The Endocannabinoid System and Treating Migraines | cannabisMD

The Endocannabinoid System and Treating Migraines

Treating migraines and headache through the ECS

The endocannabinoid system is a very recent discovery. Through this discovery, scientists and medical experts have been able to conduct a vast amount of research on this system and the cannabis plant. In studies previously published, the anti-nociceptive effect of cannabinoids has been unequivocally demonstrated in models of inflammatory and neuropathic pain, although some controversies exist on the localization of these pain-protective effects.

Here is the full scientific article if you wish to download it.

How Does The Endocannabinoid System Work?

The Endocannabinoid System is a unique communications system involving the brain and the body. It is named after the marijuana plant Cannabis sativa and it’s chemical compound THC (delta-9-tetrahydrocannabinol).

The ECS is made of of what’s called receptors and cannabinoids. These cannabinoids are located all around the body and receptors CB1 and CB2 play a vital role in the ECS. The receptors regulate important bodily functions. These boldi functions include:

  • The immune system
  • The Central Nervous system

All of which, in turn, can improve a person’s:

  • Mood
  • Appetite
  • Slepp
  • Memory

The ECS is also known to reduce and treat addictions, even substance abuse and alcoholism.

What Role Does The Endocannabinoid System Play in Treating Migraines?

Additionally, some studies have reported hyperalgesia in response to systemically administered antagonists of CB receptors, whereas several others have reported evidence against a role for the endocannabinoid system in the tonic inhibition of pain.

This study did not elucidate the relative contributions of CB1Rs and CB2Rs, but it suggested that both cannabinoid receptors, as others yet unidentified CB receptors and potentially synergistic effects between them, may contribute to cannabinoid analgesia. In conclusion, activation of ECS represents an interesting potential tool for reducing physiological as well as inflammatory pain the types of pain most likely involved in migraine attacks although the involved mechanisms need further investigation.

Jonathan Neilly
Jonathan Neilly
Jonathan Neilly is registered with the British Psychological Society, breaking the taboo on mental health issues is one of the driving forces in his life. His background in biomedicine gives him additional understanding of the factors that work together to influence the human condition.

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