The endocannabinoid system is a very recent discovery. Through this discovery, scientists and medical experts have been able to conduct a vast amount of research on this system and the cannabis plant. In studies previously published, the anti-nociceptive effect of cannabinoids has been unequivocally demonstrated in models of inflammatory and neuropathic pain, although some controversies exist on the localization of these pain-protective effects.
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The Endocannabinoid System is a unique communications system involving the brain and the body. It is named after the marijuana plant Cannabis sativa and it’s chemical compound THC (delta-9-tetrahydrocannabinol).
The ECS is made of of what’s called receptors and cannabinoids. These cannabinoids are located all around the body and receptors CB1 and CB2 play a vital role in the ECS. The receptors regulate important bodily functions. These boldi functions include:
All of which, in turn, can improve a person’s:
The ECS is also known to reduce and treat addictions, even substance abuse and alcoholism.
Additionally, some studies have reported hyperalgesia in response to systemically administered antagonists of CB receptors, whereas several others have reported evidence against a role for the endocannabinoid system in the tonic inhibition of pain.
This study did not elucidate the relative contributions of CB1Rs and CB2Rs, but it suggested that both cannabinoid receptors, as others yet unidentified CB receptors and potentially synergistic effects between them, may contribute to cannabinoid analgesia. In conclusion, activation of ECS represents an interesting potential tool for reducing physiological as well as inflammatory pain the types of pain most likely involved in migraine attacks although the involved mechanisms need further investigation.