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Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
One of the main barriers when examining CBD as an oral treatment, is overcoming the bell-shaped dose-response curve.
Firstly, let’s bust the jargon;
Bell-shaped curve – a “normal distribution” with a peak in the middle (image below)
Dose-response curve – a graph that shows the how effective a treatment is at different doses
As the graph below shows, as the dose increases, the effect starts to reduce after a peak. There are a couple of reasons this is significant;
Generally, medicines plateau, rather than peak. This makes dosage recommendation easier for standard medicines as the effective range is bigger.
As everyone’s’ biology differs slightly, the effective range is difficult to identify for each person.
Healing was only observed within a very limited dosage range for CBD. This means there was no beneficial effect when the dose was too high or too low. This narrow window in which CBD has an effect, makes it difficult to implement in clinics.
The researchers searched for a better preparation that would allow the therapeutic effects of CBD to be used more easily. The aim was to “eliminate the bell-shaped dose-response curve of cannabidiol. This study focuses on Cannabis clone 202.
This variant contains a higher than average amount of CBD. It also contains only trace amounts of THC. This makes it a good candidate for CBD research. The researchers compared the clone 202 extracts to purified CBD.
Therapeutic Effects Drop At A Higher Dosage
The results found that both the purified CBD and clone 202 extracts reduced inflammation and swelling. However, the effects of the purified CBD were only seen at a very limited range of doses. This links CBD to the dose-response bell curve (above). The therapeutic effects dropped rapidly as the dosage started to get higher or lower.
The clone 202 extract results, were much more promising. The researchers deduced that the clone 202 extract functioned more like a standard medicine. In the test subjects in fact, when compared to aspirin, the clone 202 extract even exhibited superior anti-inflammatory properties.
It’s important to note that the subjects in this experiment were not human. However, this article is some really good progress into the use of cannabidiol as a medicine. With further research, we are likely to have a really effective, natural medicine.