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Post-ischemic treatment with cannabidiol prevents electroencephalographic flattening, hyperlocomotion and neuronal injury in gerbils
A cannabinoid is one of a great collection of complex chemical compounds that operates on cannabinoid receptors in cells that change neurotransmitter release in the brain. Cannabinoids for these receptors include the endocannabinoids, that are made naturally in the body by animals, the phytocannabinoids in cannabis and some other plants, and synthetic cannabinoids. The main cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive chemical in cannabis. Cannabidiol (CBD) is another main constituent of the plant and produces a non psychotic effect . This paper will look at cannabidiol as a therapeutic for brain injury in gerbils.
Therapeutic role of cannabidiol
The budding enterprise of cannabidiol, a non-psychoactive effect derivative of cannabis, in ceasing damage caused by cerebral ischemia was evaluated. CBD (1.25–20 mg/kg) was administered 5 minutes after 10 minutes hyperlocomotion in alive gerbils. Seven days after ischemia, the neuroprotective effect was at its peak with 5 mg/kg. One day after ischemia CBD absolutely disfigured the ischemia-induced hyperlocomotion, at every single dose. These results indicate a possible therapeutic position in CBD in cerebral ischemia, though the transparent working method still comes as a mystery.
Anti inflammation abilities of cannabidiol
CBD was working against ischemia-induced hyperlocomotion at every single dose evaluated. One explanation is that triggering of VR1 receptors by the greatest doses may have a locomotor activity, as displayed in rats and mice. Cannabinoids make hypothermia, which is neuroprotective in some instances. However, any such impact can be taken out in these experiments since body temperature was made constant during the early parts and the chemical had no hypothermic side effect. CBD has been found to stop clinical signs of arthritis in a murine collagen-induced arthritis experiment. Since cytotoxic and vasogenic edema makes itself known during and after hyperlocomotion in gerbils, an antiinflammatory activity of CBD and THC on cerebral ischemia cannot be excluded.
Overall, CBD given after ischemic happenings in gerbils spurred the hyperlocomotion by allowing the survival of certain neurons in the brain. Future research is needed so the mechanism of exact action is brought to the surface, but these results, together with the well-described low toxicity, indicate its possible treatment role as an anti-ischemic agent for this naturally occurring nonpsychoactive constituent of cannabis.Post-ischemic_treatment_with_cannabidiol