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The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model
Cannabinoids are a group of chemical compounds that come from the cannabis plant (cannabis sativa). Cannabidiol (CBD) is one of these chemicals and studies have suggest that it has anti inflammatory effects when induced in animals. Tetrahydrocannabinol (THC) is another one of these compounds that wields a psychoactive effect in animals. Cannabinoid receptors (CB1 and CB2) are found in the endocannabinoid system and allow cannabinoids to bind and do their job in the body. This paper will look at how CBD cannabis and THC can work in the body to enhance the anticancer effects of radiation in a glioma modeled experiment.
Cannabinoids have clinical benefit to glioma patients
Glioma is regarded as one of the most malignant cancers in adult humans and long-term survival rates are quite low as normal treatments for glioma are hugely unsuccessful. Cannabinoids have displayed to particularly stop glioma development as well as normalize cell functioning. In an effort to better treatment result, scientists evaluated the impact of THC and CBD, both alone and in cahoots with radiotherapy in numerous glioma cells. Cannabinoids were cultivated in two forms, pure (P) and as a botanical drug substances (BDS). Conclusions displayed a reduction in cell visibility with each cannabinoid and indicated that THC-BDS was more effective than THC-P, on the other hand, CBD-P was more effective than CBD-BDS. These conclusions were emphasised in a model for glioma, which displayed massive decreases in tumor sizes when both cannabinoids were used with irradiation. Taken together, these results emphasise the importance that these cannabinoids have in major glioma cells that respond better to radiation, and indicate a possible clinical advantage for people with glioma by using these two treatment types.
Cannabinoids have anticancer properties
Overall, these results add further indications that cannabinoids both alone and with each other, hold anticancer abilities. The impacts that CBD and THC have on the main intracellular transmissioning pathways responsible for controlling cell growth and survival are emphasised in this report. Successful results were noted, where the triple mixture of CBD products, THC, and irradiation massively inhibited tumor development in a the glioma model. It is now detrimental to the development in this research to understand the biologic basis of this advancement. In previous studies it was shown that the schedule with which cannabinoids are dosed is important, and so these questions are being touched on in current work. Overall, this research gives us wider knowledge of how best these chemicals should be used most efficiently and how a mixture of cannabinoids and irradiation can be applied to better the effectiveness of glioma treatment.2955.full-min