Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.
CBD is a rapidly growing area of research due to its wide range of uses without side effects. This paper investigated the research available in vivo (in real living beings, not test-tubes), for the effects of CBD therapies on a range of psychiatric disorders. These include anxiety, depression, and psychosis. Anxiety and depression are often linked closely, as their symptoms overlap. Psychosis, a less common disorder, is the name for a severe mental disorder in which thought and emotions are so impaired that contact is lost with external reality.
This sounds much more complicated than it is. The much old research discovered nothing, and this was attributed to CBD having little or no effect on many things. This bell-shaped dose-response curve makes CBD’s use in the clinic and in research more of a challenge. If the dose is above or below the optimum range, there is little to no effect. For example, maybe 10 drops of CBD gives the best results in the treatment of a disease. 8 drops would produce no effect, but neither would 12 drops. Though in reality, it is much more complex than this.
Here is the full scientific article if you wish to download it.
A study found that CBD therapy decreased stress, panic attacks, and PTSD episodes. Though there are some conflicting results on this. Freezing as part of a fear response increased with CBD treatment. Though this may depend on dosage or the dosage regime. CBD has also been shown to reduce and prevent some of the results of “inescapable stress”
One study reviewed in this paper suggested that CBD treatment may be useful in cases of obsessive-compulsive disorders. Though this was deduced from an investigation that was only a preliminary study. Further research is definitely needed in this area. With regards to psychosis, CBD has been seen to counteract the effects of THC. THC has the ability to induce psychosis in certain situations. CBD poses a potential use for psychosis, though again, further research in this area is needed as a lot of important understanding is missing.
The researchers offered a lot of support in favor of CBD and its ability to treat depression, though they do state that most types of depression investigated are those that arise from high stress or PTSD like triggers.