CB2 receptor’s part in the AD and potential benefits of certain agonists the receptors have an opposing AD, all this is discussed in the review below. Cognitive damage in animal representations of the AD can be improved with activation of the CB2 receptor. Keywords: cannabinoids, tau, neuroinflammation, CB2 receptor, Alzheimer, β-amyloid, oxidative stress. Go to: Summary of Alzheimer’s disease: it is a neurodegenerative disease dependent on age, marked by a slow spreading of cognitive deterioration with devastating consequences.
Within animal representations of the AD, an increase in CB2 PET binding in the brain is reported. In the AD, particular CB2 staining has also been seen indystrophic neurites from frontal cortex and in tangle-bearing neurons. It’s fascinating to note that settlement of plaque and Aβ42 levels, both are correlated with CB2 receptors’ levels of expressions. But no correlation exists with cognitive standing. This suggests that such infection-causing occurrences cause expression of CB2 receptors.
Go to: a CB2 receptor in treating AD because of its therapeutic effects: experimental models of the past decade provide support that evidence is shown by many studieson the possible therapeutic characteristics of CB2 receptor targeting compounds. The results were shown within both animal and cellular models which mimic many alterations related to AD.
In old mice inflicted with an AD in which CB2 receptors are absent, a little decrease in plaque content and soluble Aβ is shown. This suggests that the involvement of CB2 receptor in the processing of Aβ could differ, as could the development of the neurodegenerative process.
Similar cognitive functions were seen between the mice mimicking AD in which CB2 receptors were absent and those mice that were under transgenic control. This proposes that in the matter of cognition, a direct role isn’t executed by the CB2 receptors.
Go to: Taking inferences and future views together, it is seen that currently, experimental examinations show that expression of CB2 receptors is induced by the AD and that favorable outcomes can be seen in the AD when CB2 receptors are focused on.Inflammation connected with producing and depositing Aβ is decreased by agonists of CB2 receptors, that also help clear Aβ and enhance cell vitality when Aβ exists.
The dissemination of pro-inflammatory molecules is decreased with the help of CB2 receptors. These receptors also help clearance of Aβ through their assistance of microglia phagocytic phenotype, resulting in a reduction of Aβ… Taking into account the evidence of pleiotropic action, along with the fact that CB2 receptors don’t have any serious or grave psychoactive effects, the compounds behaving on these cannabinoid receptors are portrayed to be a potential means of therapy for the AD. Despite all of this, it’s important to mention that there is no information available about the reliability or harmful nature in human beings about the compounds which particularly target CB2 receptors. This also means that information on possible side effects, like immune suppression, may be unveiled.