Is the Cardiovascular System a Therapeutic Target for Cannabidiol? | cannabisMD

Is the Cardiovascular System a Therapeutic Target for Cannabidiol?

Cannabiniods to target cardiovascular system therapeutically

Cardiovascular disease, better known as heart disease, kills about 610,000 Americans each year. This makes it one of the biggest killers in the United States today, and a health risk so severe that it requires serious consideration and prevention.

As a result, scientific researchers have for some time being investigating alternative treatments for heart disease. One such treatment is cannabidiol.

Cannabidiol, more commonly called CBD, is one of the chemicals found in the cannabis sativa plant. This chemical has been studied extensively as a potential therapy for everything from Crohn’s disease to acne. However, it is in the area of heart disease where it is currently showing significant promise.

Scientific Research

One recent study presents evidence of the positive effects of CBD in the cardiovascular system. In isolated arteries, direct application of CBD causes both acute and time-dependent vasorelaxation of preconstricted arteries and enhances endothelium-dependent vasorelaxation in models of endothelial dysfunction.

In vivo, CBD treatment does not appear to have any effect on resting blood pressure or heart rate, but does reduce the cardiovascular response to various types of stress.

In vivo, CBD treatment has a protective role in reducing the effects of cardiac ischaemia and reperfusion, or in reducing cardiac dysfunction associated with diabetes.

Similarly, CBD has a protective role in reducing the ischaemic damage in models of stroke, partly due to maintaining cerebral blood flow. In models of altered vascular permeability, CBD reduces the hyperpermeability of the BRB in diabetes and BBB hyperpermeability after LPS injection.

Similarly, CBD ameliorates the negative effects of a high glucose environment on cell adhesion molecules and barrier function.Together, these data suggest that the cardiovascular system is indeed a valid therapeutic target for CBD.

However, the target sites of action for CBD remain to be established for most of these responses. Whether these responses to CBD will translate into the human cardiovascular system also remains to be established.

More research is needed if CBD is to be used as a legitimate treatment for cardiovascular disease in the future. However, the strides which are currently being made by medical researchers in this field show sufficient promise to continue investigations with cautious optimism.

Here is the full scientific article if you wish to download it.

Jonathan Neilly
Jonathan Neilly
Jonathan Neilly is registered with the British Psychological Society, breaking the taboo on mental health issues is one of the driving forces in his life. His background in biomedicine gives him additional understanding of the factors that work together to influence the human condition.

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