Cannabinoids Therapeutic Potential Aganist Cociane | cannabisMD

Cannabinoids Therapeutic Potential Aganist Cociane

Cannabinoids Therapeutic Potential Against Cocaine; National Institute of Health

National Institute of Health

Cannabinoids are a group of chemicals that come from the cannabis plant (cannabis sativa). Cannabidiol (CBD) is one of these chemicals and studies have suggest that it has anti inflammatory effects when induced in animals. Tetrahydrocannabinol (THC) is another one of these compounds that wields a psychotropic effect in animals. Cannabinoid receptors (CB1 and CB2) are found in the endocannabinoid system and allow cannabinoids to bind and do their job in the body. The aim of this study will be to give insights into the complex image of cocaine use and addiction and to evaluate the therapeutic potential of medical marijuana to act as enhancers against cocaine use for clinical trials.

Here is the full scientific article if you wish to download it.

Main Points

  • Cannabis has a potential to reduce cocaine use of addict
  • Endocannabinoids may be enhanced in the body to alleviate drug dependence

Cannabis has a potential to reduce cocaine use of addict

Studies of how cannabinoid receptors behave when agonists are induced have been carried out to determine agonists role in reducing cocaine effects. This has led to the view of cannabinoids actually having an ability to counteract the effects of cocaine. This paper says that a cannabinoid receptor, impaired by cannabinoid agonist induction, is indeed apart of plenty of the reinforcing effects of cocaine which are said to be involved in cocaine abuse and addiction. However, there is no current knowledge about the interactions of drugs acting as cannabinoid levels modulators/enhancers on cocaine-induced behaviors.

Endocannabinoids may be enhanced in the body to alleviate drug dependence

Papers have suggested that that crack cocaine dependence is because of a genetic weakness and this has led to the belief that this vulnerability of the cannabinoid receptor 1 gene makes the endocannabinoid system linked to cocaine. Cannabinoid receptors are in abundance in the brain and they have a big role in drug abuse and addiction. This was realised by the different expression and regulation of cannabinoid receptors (CB1 and CB2) induced by genetic differences and how important of a factor it is to the weakness to drug dependence. Endocannabinoid receptors were then targeted in this study to become uptake inhibitors or metabolism blockers in mice.

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