While some research points that the use of Cannabis sativa at a young age may increase the risks of psychotic disorders, one being schizophrenia. Schizophrenia is characterized as being a developmental brain disease marked by hallucinations, delusions, disorganized thinking, as well as negative social and occupational effects, and cognitive deficiencies.
There are treatments available that have had positive outcomes when dealing with the negative symptoms of schizophrenia, however, there is still no development of a treatment that is able to reverse the disability linked to cognitive deficits and detachment, blunted emotions and drives.
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Cannabis use if often associated with being a psychoactive trigger in psychotic disorders, but it is likely that this correlation can be made due to a causal relationship as well as self-medicating behaviors. The endocannabinoid system (ECS) has two main receptors, cannabinoid 1 receptor (CB1R) and the cannabinoid 2 receptor (CB2R).
The CB1R is found in the central nervous system, while CB2R is in the peripheral tissue and organ throughout the body. “Interactions between the endocannabinoid and dopaminergic system have been thought to play a role in the relationships between cannabinoids and psychosis.
Higher levels of CB1R, such as via the full agonist endocannabinoid 2-AG or through exogenous cannabis such as THC, may, directly and indirectly, contribute to dopaminergic dysregulation in brain areas important to psychosis, such as frontal cortical areas and the hippocampus.”
On the other hand, Cannabidiol (CBD), is a non-psychoactive cannabinoid found in cannabis. CBD actually counteracts various effects of THC and other CB1R agonists, “including anxiety, euphoria, and psychosis”. Preclinical trials have shown that CBD the behaviors of schizophrenia in rodents. CBD has also been found to have neuroprotective qualities, as well as anti-inflammatory effects in the brain. Individuals who are in early onset or found to be at risk of psychosis may find CBD treatment beneficial.