The cannabis plant contains cannabidoil (CBD) which has been proven to have an anti inflammatory effect in animal cells. The CB1 and CB2 receptors in the endocannabinoid system are agonised by cannabinoids and this results in anti inflammation and improvement in cognitive function. Problems arising from vascular dementia are quite hard to treat as antipsychotic medicine come with significant risks and many medical agencies do not recommend there use. This paper looks at the synthetic cannabinoid nabilone for improving the patients with symptoms of dementia.
Synthetic cannabinoids known to treat a number of conditions such as nausea, anorexia, pain and anxiety. Tetrahydrocannabinol (THC) is another constituent of cannabis and it is said to have disease-modifying effects in Alzheimer’s disease. This process involves reduced neuronal toxicity and also reduced amyloid aggregation. The synthetic cannabinoid dronabinol was found in other studies to improve anorexia as well as nocturnal agitation in people with dementia.
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In this paper, naboline was given to dementia patients and this reduced the severity of their aggression dramatically. The possible side effects of naboline include drowsiness and increased agitation. It is recommended that it is taken in small doses to avoid side effects.
The mixture of naboline with non-antipsychotic medicines such as cholinesterase inhibitors, memantine and anti depressants, can have positive influence in the treatment of patients with dementia. In this paper, by agnosing cannabinoid receptor with nabilone, dramatic behavioural improvements were made in dementia patients with psychological symptoms.
Overall, there was a reduction in dementia patients response to aggression towards the staff at the care home. Naboline has been proven to be a safe medication for people with persistent dementia and this comes at a good time as there is only a few medications available to patients who need a long term viable remedy. This paper suggests that cannabinoid receptors and the effects of cannabinoids should be studied further as it has the potential to relieve people with different types of dementia.