Cannabinoids Role in Chemotherapy-Induced Nausea | cannabisMD

Cannabinoids Role in Chemotherapy-Induced Nausea

Cannabinoids Role in Chemotherapy-Induced Nausea; Dovepress


Cannabinoids are a collection of over 100 chemicals that are derived from the cannabis plant (cannabis sativa). Cannabidiol (CBD) is one of these chemicals and research has said it has anti inflammatory effects when induced on animal cells, without unwanted psychoactive side effects. Tetrahydrocannabinol (THC) is another one of these chemicals that gives off a psychotropic effect in animals brains. Endogenous cannabinoid receptors (CB1 and CB2) are found in the endocannabinoid system and allow cannabinoids to bind and work in the body. This paper will look at a synthetic cannabinoid, Nabilone, and its role in chemotherapy related side effects such as nausea and vomiting.

Here is the full scientific article if you wish to download it.

Main Points

  • Naboline could be used in chemotherapy treatment
  • Naboline, a cure for nausea?

Naboline could be used in chemotherapy treatment

Chemotherapy-induced nausea and vomiting in people with cancer places a massive burden on people’s function and quality of life, their families and caregivers, and healthcare providers. Despite the developments in preventing nausea, a substantial proportion of patients experience persistent nausea and vomiting. Nabilone, a cannabinoid, recently received FDA approval for the treatment of the nausea and vomiting in people getting cancer chemotherapy who do not achieve proper relief from conventional treatments. The cannabinoids exert anti inflammatory effects via agonism of CB1 and CB2. Clinical trials have shown the benefits of nabilone in cancer chemotherapy patients.

Naboline, a cure for nausea?

Cannabinoids have been shown to have effects in a variety of clinical syndromes, including nausea and vomiting arising from chemotherapy. Nabilone, a newly approved synthetic cannabinoid agonist, has long been used to stop vomiting. Nabilone may have a job in those patients whose nausea as an anti emetic. More study of nabilone as a therapy is needed in these areas. There is also a developing body of papers to suggest additional benefits in cancer patients, including pain management. More study of synthetic cannabinoids may provide more indications, not only in people with malignant diseases, but also with people with non-malignant diseases.

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