© 2018 Miraculo Inc. All Rights Reserved
Effects of cannabinoid treatment on Chagas disease pathogenesis: balancing inhibition of parasite invasion and immunosuppression
Cannabinoids are found in the marijuana plant (cannabis sativa) and are said to be effective in pain management from pain symptoms such as multiple sclerosis and nausea and vomiting. A cannabinoid is one of a great collection of complex chemical compounds that naturally occur in the body and operates on major cannabinoid receptors in cells that mediates neurotransmitter release in the brain. Cannabinoids for these receptors include the endocannabinoid system, that are produced in the body by animals, the phytocannabinoids in cannabis and some other plants, and synthetic cannabinoids. The main endogenous cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive chemical in cannabis. Cannabidiol (CBD) is another main constituent of the plant and produces a non psychotic effect, and is also said to have an anti inflammatory effect. Cannabinoids have a therapeutic potential no doubt, however they are yet to be studied in depth to treat a wide range of human pathologies. This paper will look at how cannabinoids can be used in the treatment of chagas disease.
Cannabis has a therapeutic potential in chagas disease
Trypanosoma cruzi infects heart cells by way of the calcium‐dependent, G protein‐controlled system, pointing to serious cardiac inflammation considered by a few to be autoimmune in design. It is spread by triatomine bugs in latin america and affects millions of people in south america. Cannabinoids induce calcium flux and G protein transmissioning; as strong immunosuppressive drugs, they are efficient in the curing of autoimmune disorders but contra suggested for the curing of infections. This study contrasted the method of the synthetic cannabinoid R(+)WIN55,212 and its inactive isomer S(–)WIN55,212 on cardiac myoblast invasion: R(+)WIN55,212 induced infestation by over 85%. Researchers then assessed for effectiveness in changing pathogenesis in mice by assaying parasite trypanosoma cruzi concern in heart and blood, cellular and humoral immunity to parasite and self antigens, and mortality. R(+)WIN55,212 massively decreased cardiac inflammation but made massively increased parasitaemia. Cardiac parasitosis and mortality were not massively contrasting in treatment and regulation groups. Researchers have finally said that cannabinoids can prevent cardiac cell damaging fixing actions, thereby inducing trypanosome infestation as foreseen by the mechanism of agent method, but, also induce immune cell impact or functions, offsetting the favour of induction parasite cell infestation. Refined application of cannabinoids may confirm therapeutic in the future, but these conclusions shed light on the burden about the impact of marijuana use on those chronically induced by T. cruzi and on heart cell homeostasis normally.
Implications of cannabis in chagas disease
It is known that cannabinoids can have the ability to kill the parasite when signs and symptoms persist in the chronic phase of chagas heart failure.
Overall, it is noteworthy that marijuana is widely applied in places where Chagas infection is endemic, for example as maconha in the Northeastern regions of Brazil. This research indicates that disorder of broad‐spectrum cannabinoids might be important to people with the disease. It is noteworthy though, that the murine experiment researchers employed in this study is limited to the acute part of infection. Therefore, following the results in a chronic experiment may prevent more insight into the complications of marijuana use during human disorder pathogenesis. Recently, no epidemiological research has been released into the world with which to correlate these results. However, more research are needed to further delve into the actions involved in the dichotomy of cannabinoid treatment for Chagas disease. Researchers have illustrated that R(+)WIN55,212 has a massive inducing impact upon the adaptive immune response and can increase blood parasitaemia. Therefore, this research has detrimental pathological implications for cannabis application infested with T. cruzi parasites.