Cannabinoids are a group of chemicals that are found in the cannabis plant (cannabis sativa). It’s extracts have been used to make medicine for thousands of years. Cannabidiol (CBD) and tetrahydrocannabinol (THC) are the main constituents in the plant and are said to have anti inflammatory properties on animal cells. Cannabinoid receptors have been recently found in the body and these allow cannabinoids to bind in the body and work in the endocannabinoid system. Cannabinoids have been said to have a therapeutic value, although because of it’s highly addictive and psychoactive nature, people have abused it and in turn, governments have banned it. A multiple amount of diseases are known to be treated by marijuana. These include pain, inflammation, MS, Parkinson’s, epilepsy and schizophrenia. This paper will look at the role cannabinoids have in health and disease, and how to administer cannabinoids at the right dose specific to each disease.
Here is the full scientific article if you wish to download it.
Cannabinoid receptor 1 agonists have massive therapeutic potential
Most drugs today are misused, such as cocaine and ketamine. These drugs are still important for pharmaceuticals to manipulate and be tailor made into specific drugs for specific diseases.
Medical cannabis was taken out of clinical practice because of its addictive nature but now it is being brought back in because the cannabinoid receptor 1 agonists have been found to have a massive therapeutic potential. For local action, cannabinoid receptor one agonists do not penetrate the blood brain barrier.
CBD does not have any psychoactive effects
It has been seen that synthetic cannabinoids acting specifically on cannabinoid receptor two, can cause zero psychoactivity, and this may be used on people with osteoporosis. There are also many targets additional to CB1 and CB2 that don’t cause any psychoactivity when their agonists are bound to them. CBD does not have any psychoactive effects and can have a therapeutic effect. The endocannabinoid system is vast and regulates a great amount of processes with other known systems such as the dopaminergic system. CBD in general has a massive potential in clinical trials and it should be studied more so that there are more selective distribution patterns.