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Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines
Cannabinoids are a group of chemicals derived from the cannabis plant (cannabis sativa). Cannabidiol (CBD) is one of these chemicals and research has shown that it has anti inflammatory properties to heal animals with nervous system disorders. Tetrahydrocannabinol (THC) is another one of these compounds that wields a psychoactive effect in animals. Cannabinoid receptors (CB1 and CB2) are found in the endogenous cannabinoid system and allow cannabinoids to bind and do their job in the body. This paper will look at how cannabinoids can be induced into human colon cancer cell lines and how they are beneficial to the human condition.
Cannabinoids may be good for cancer fight
Cannabinoids are a class of chemicals that have the know how to trigger two specific receptor subtypes, the cannabinoid CB1 and CB2 receptors. CB1 receptor is a G-protein-coupled receptor that is linked to the signal transduction pathways. The cumulative impacts of this receptor have detrimental implications in the mediation of cell survival and cell death having the wits to control tumor cell growth. In this connection, intrigue has been set on factors such as sex steroid hormones, which control CB1 receptor expression. CB1 gene expression was found out using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) in DLD-1, HT-29 and SW620 cells treated at contrasting times and doses of 17b-estradiol exposure. CB1 protein expression was detected by the Western immunoblot method.
Cannabinoids have antiproliferative properties
This current study gives more knowledge on the mechanisms by which estrogens can change colon cancer proliferation. It was demonstrated in the past that the inhibitory impact of estrogens on gastric cell lines. The exposure of a human estrogen receptor-positive gastric cancer cell line to progressive increasing 17b-estradiol concentrations caused a massive anti-proliferative action and an enhanced apoptotic rate, in a dose-dependent way. It was also seen that the estradiol has the ability to relate to molecules like polyamine and growth factors required for cell proliferation. Recently, it was illustrated that an estrogenic regulation of cholesterol biosynthesis and cell growth in DLD-1 human colon cancer cells, indicating that the cholesterol metabolism could be considered another target for the estrogenic antiproliferative abilities.Estrogenic-induction-of-cannabinoid-CB1-receptor-in-human-colon-cancer-cell-lines