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Interaction between non-psychotropic cannabinoids in marijuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
Cannabinoids are naturally occurring chemical compounds that originate in the marijuana plant (cannabis sativa). Cannabidiol (CBD) is the main chemical within the cannabis plant and it is said by the wide scientific community that it has anti inflammatory effects when induced into animal cells. Tetrahydrocannabinol (THC) is another one of these chemicals and it is said to have a psychotropic effect. Major cannabinoid receptors (CB1 and CB2) are located in the endocannabinoid system and gives endogenous cannabinoids power to bind and work in the body. The aim of this study is to evaluate the interaction between non-psychotropic cannabinoids in medical marijuana and the effect of cannabigerol (CBG) on the anti-nausea properties or anti-emetic effects of cannabidiol (CBD) in rats and shrews.
CBG and CBD may have polar opposite effects
The relationship between two non-psychotropic forms of cannabis, cannabidiol (CBD) and cannabigerol (CBG), were studied in this paper. The objective was to evaluate the possibilty of CBG’s performance to prevent the anti-nausea, anti-emetic side effects of CBD. In experiment 1, rats were given CBG and CBD after it. In experiment 2, Suncus murinus (shrew) were given CBG and CBD after it. Results showed that CBD stopped the progression of conditioned gaping in rats and vomiting in shrews. CBG was seen to not help the nausea in the rats and shrews. This has led to the conclusions that the relationship between doses of CBG and CBD may oppose one another at the cannabinoid receptors in the mediation of nausea and vomiting.
CBD may have anti nausea effects
Chemotherapy-induced nausea remains a massive clinical hurdle. Cannabis oil may be used to treat nausea; however, people who smoke cannabis products are succumbed to over 60 cannabinoids. Although the THC content in the more stronger types of cannabis has bettered over the past 10 years, the dose of both CBD and CBG has remained the same. The report of this study indicates that it may be more efficient to treat nausea and vomiting with specific cannabinoids that have been seen to hold anti-nausea effects, like CBD, rather than with cannabis, which is psychoactive and wields cannabinoids, such as CBG, that stop the anti-nausea impacts of other cannabinoids.Interaction-between-non-psychotropic-cannabinoids-in-marihuana-effect-of-cannabigerol-CBG-on-the-anti-nausea-or-anti-emetic-effects-of-cannabidiol-CBD-in-rats-and-shrews