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Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy
A cannabinoid is one of a great collection of complex chemical compounds that operate on cannabinoid receptors in cells that fluxuate neurotransmitter release in the brain. Cannabinoids for these receptors include the endocannabinoids, that are made naturally in the body by animals, the phytocannabinoids in cannabis and some other plants, and synthetic cannabinoids. The main cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive chemical in cannabis. Cannabidiol (CBD) is another main constituent of the plant and produces a non psychotic effect. This paper will devour a plate full of cannabinoids and within, their potential to toy with epilepsy’s functioning in the body.
Endocannabinoid system may have a role in the treatment of epilepsy
Epilepsy is a massive medical emergency related to an important significant morbidity and mortality advancement of epilepsy. Cannabinoids hold anticonvulsant abilities and the endocannabinoid system has been affected in regulating how long a seizure persists. Endocannabinoids control synaptic transmission and kills seizure activity via triggering of the presynaptic cannabinoid receptor 1 (CB1). This research was conjured up to review the position of CB1 receptor-dependent endocannabinoid synaptic signalling towards stopping the evolution of epilepsy sustainability in the well-described hippocampal brain experiment of epilepsy. Adaption of the CB1 receptor agonist to epileptic brains caused the advancement of persistent activity of epilepsy. These results present the thought that CB1 receptor agonists could possibly act as a modulator in frequency and seizure duration to reduce the persistence of epilepsy.
Cannabinoids as a therapeutic for epilepsy
Poking the CB1 receptor would stall their response by its endogenous cannabinoids, thereby helling the endocannabinoid breathing ground and it’s paralleled control panel of neuronal plausibility. This research was conducted to answer the CB1 receptors invitation of exciting the neuronal grouch in epilepsy. The armour of the endocannabinoid system has been touched for a therapeutic agent candidacy in spying on methods to treat epileptic symptoms such as pain, obesity, glaucoma and migraine. Future installations in the endocannabinoid-epilepsy series might render some reasons into why this therapeutic potential exists.nihms14433