Cannabinoids as Novel Anti-Inflammatory Drugs | cannabisMD

Cannabinoids as Novel Anti-Inflammatory Drugs

anti inflammatory drugs and cannabidiol

According to an FDA (Food and Drug Administration) article, about 103,000 people per year are hospitalized because of a nonsteroidal anti inflammatory drug overdose (NSAID). Comparing cannabis in this case, it may not hold the same danger, as it is believed that you cannot over-dose with it. Although NSAIDs are usually safe to take in small doses, there are also people that find that these types of drugs have no real effect on them and can become quite addictive.

It is becoming increasingly clear that cannabinoid receptors and their endogenous ligands play a crucial role in the regulation of the immune system. Exogenous cannabinoids have been shown to suppress T-cell-mediated immune responses by primarily inducing apoptosis and suppressing inflammatory cytokines and chemokines. Such observations indicate that targeting cannabinoid receptor–ligand interactions may constitute a novel window of opportunity to treat inflammatory and autoimmune disorders. As CB2 receptors are primarily expressed on immune cells, targeting CB2 may result in selective immunomodulation without overt toxicity.

Here is the full scientific article if you wish to download it.

The future challenges for the use of cannabinoids as anti-inflammatory drugs include synthesis of cannabinoid receptor agonists that are non psychoactive with anti-inflammatory activity and then identifying their mode of action. Although current studies suggest that cannabinoids are useful therapeutic agents in the treatment of various inflammatory disorders, further evaluation of the mechanisms that account for their anti-inflammatory properties is necessary.

Overall, cannabinoids have exhibited significant potential to be used as novel anti-inflammatory agents and specific targeting of CB2 receptors holds the promise of mediating immunosuppressive effects without exerting psychotropic side effects. The use of cannabinoids to treat inflammatory diseases is thoroughly being investigated and until further studies become more funded, we cannot certainly detail the positive and negative impacts that it may include.

If you wish to use cannabinoids as a form of treatment, consult your doctor first.

Jonathan Neilly
Jonathan Neilly
Jonathan Neilly is registered with the British Psychological Society, breaking the taboo on mental health issues is one of the driving forces in his life. His background in biomedicine gives him additional understanding of the factors that work together to influence the human condition.

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