Cannabinoids Properties Vs. Oxidative Stress | cannabisMD

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Cannabinoids Neuroprotective Properties Vs. Oxidative Stress

Journal of Neurochemistry

Cannabinoids are found in the marijuana plant (cannabis sativa) and are said to have neuroprotective effects. Cannabidiol (CBD) is one of the chemicals found in cannabinoids and tetrahydrocannabinol (THC) is the other, and this one is responsible for the psychoactive effect. The mechanism in how cannabinoids produce this neurotoxicity effect is yet unknown. This paper illustrates the antioxidant effects cannabinoids have on the brain.

Here is the full scientific article if you wish to download it.

Main Points

  • Cannabinoids have neuroprotective effects
  • CB1 receptor is not involved in neuroprotective effects of cannabinoids

Cannabinoids have neuroprotective effects

Cannabinoid receptors are found in the endocannabinoid system and are responsible for allowing cannabinoids to work in the body. Cannabinoid receptor 1 (CB1) in rats cerebellar granule cell cultures contain the CB1 protein. 3 CB1 agonists were used in this test and results show that 2 of these compounds, which were pehnolic, were able to provide neuroprotection in cerebellar neurons. The other compound, which was methanandamide, did not protect primary granule cells against oxidative nerve cell death.

CB1 receptor is not involved in neuroprotective effects of cannabinoids

8 compounds were classified into 3 groups, phenolic compounds, non phenolic compounds and phenolic compounds that don’t bind CB1. Results show that phenolic compounds that bind and don’t bind to CB1 have a similar potential against oxidative neuronal cell death in rats. Oxidative stress experiments were also carried out in this experiment and results strongly support that CB1 is not involved in the cellular antioxidant neuroprotective effects of cannabinoids.

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