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Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.
Cannabinoids, such as CBD are well known as having anti-inflammatory properties and an inhibitive effect on many recurring skin problems. This is because it interacts with tumorigenic cell lines, which are present in human skin and are linked to the symptoms of a variety of skin diseases including Psoriasis.
Psoriasis is an inflammatory disease that is characterised in part by epidermal keratinocyte hyperproliferation.This is linked to the human body’s endocannabinoid system, this is what allows CBD, a cannabinoid to help control the symptoms of psoriasis.
Cannabinoid receptors are present in the human skin, allowing CBD to be directly applied as a topical ointment. When this is done CBD connects to the endocannabinoid receptors and begins to exert its anti-inflammatory properties.
All the cannabinoids tested helped inhibit the severity of psoriasis on the patient’s skin, showing that a topical CBD cream may help patients control their symptoms and have less frequent breakouts.