Cannabinoids in the Treatment of Chronic Pain and Isomnia | cannabisMD

Cannabinoids in the Treatment of Chronic Pain and Isomnia

Cannabinoids in the Treatment of Chronic Pain and Isomnia; National Institute of Health

National Institute of Health

Use of a Synthetic Cannabinoid in a Correctional Population for Posttraumatic Stress Disorder–Related Insomnia and Nightmares, Chronic Pain, Harm Reduction, and Other Indications

Cannabinoids are a collection of naturally occurring chemical compounds that are situated in the marijuana plant (cannabis sativa). Cannabidiol (CBD) is the main chemical within the cannabis plant and it is said by the wide scientific community that it has anti inflammatory effects when induced into animal cells. Tetrahydrocannabinol (THC) is another one of these chemicals and it is said to have a psychotropic effect. Major cannabinoid receptors (CB1 and CB2) are located in the endocannabinoid system and gives endogenous cannabinoids power to bind and thrive in the body. This paper will look at how the synthetic cannabinoid nabilone can be applied to treat patients with mainly different types of chronic pain, post traumatic stress disorder, insomnia, among other human pathologies.

Main Points

  • Nabilone effective in treating chronic pain
  • Nabilone can treat insomnia and PTSD

Nabilone effective in treating chronic pain

Nabilone is a synthetic cannabinoid that has displayed promise for the treatment of posttraumatic stress disorder (PTSD) associated insomnia and nightmares as well as effectiveness in the controlling of chronic pain. It has also been suggested for harm decreasing in cannabis dependence. Its efficiency to reduce pain and for controlling recurrent syndromes in severe mentally ill people has not yet been reviewed. This study took 104 male inmates with severe mental illness and gave them nabilone to look at the indications, effectiveness, and safety of its application. The conclusions suggest that nabilone targeting a mean of 3.5 indications per patient, thus potentially good at decreasing adverse side effects. PTSD-associated insomnia, nightmares, PTSD symptoms, and Global Assessment of Functioning were seen to improve when nabilone was induced.

Nabilone can treat insomnia and PTSD

The results of this study is in line with previous papers on nabilone showing promise as an effective drug in the treatment of PTSD-related insomnia and nightmares and is an efficient treatment for chronic pain. It also may incidentally be good for a harm reduction method in cannabis-dependent specific people, although this research was not able to speak to this. It is specifically noteworthy that in most people, nabilone was going for numerous symptoms at the same time, which might have assisted to prevent the risks from coming into fruition in the form of adverse side effects. The most standard suggestion in the research population were PTSD-related insomnia and nightmares, chronic pain, and harm reduction. Side effects were for the most part small and not difficult to control, and when they did happen, tended to occur early in the first month of treatment.

jcp-34-559

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