Neuropathic pain can be caused by numerous factors. Some of these factors include head trauma for an accident, a contracted infection or a chronic pain. Cannabinoids have been said to be able to treat chronic pain through their neuroprotective and anti inflammatory properties. Cannabinoids are naturally found in the medical marijuana plant (cannabis sativa). Cannabinoids include tetrahydrocannabinol (THC) and cannabinol (CBD).
THC is the psychoactive part of cannabis and gives you the stoned feeling when smoked. CBD is the medicinal part of medical cannabis and this gives you the feeling of being relaxed. The endocannabinoid system bares two cannabinoid receptors, 1 and 2, that allow cannabinoids to bind and work throughout the body.
Here is the full scientific article if you wish to download it.
This paper will look at the efficiency of cannabinoids in the regulation of patients with chronic malignant pain.
The goal of this review was to carry out a systematic evaluation to test the efficiency of cannabis extracts and cannabinoids in the regulation of chronic nonmalignant neuropathic pain. Randomized placebo-controlled trials (RCTs) inhibiting marijuana and cannabinoids for the therapeutics of chronic nonmalignant pain were chosen.
Outcomes considered were decreasing in pain intensity and side effects. Of the 24 experiments that evaluated chronic neuropathic pain, 11 experiments were excluded. The 13 included experiments were rated using the Jadad Scale to evaluate bias in pain research. Evaluation of these research indicated that cannabinoids may promote efficient therapeutics in chronic brain pain situations that are refractory to other therapeutics.
Marijuana based medicinal solutions applied in different populations of chronic nonmalignant neuropathic pain patients may give effective therapeutics in conditions that are refractory to other therapeutics. Further high-quality experiments are required to test the impact of the duration of the therapeutics as well as the greatest type of drug inducing.
Newer delivery procedures for cannabinoids are much more secure than smoking. Oromucosal spray (cannabis sativa) networks provide more consistent blood rates and thereby allow titration to efficient rates of therapeutics while minimizing adverse events. The oromucosal delivery networks also promote a level of addiction protection by preventing the amount of daily applications. Other advantages of cannabinoids seem to involve improvement in sleep quality, appetite, nausea, and anxiety.
Recently advanced synthetic cannabinoids, such as CT-3, await more evaluations in order to see their efficiency in a number of chronic pain conditions and to compare their side impact profiles with normal synthetic cannabinoids, such as dronabinol and nabilone, as well as along with fresher cannabinoid solutions. Overall, cannabis for chronic pain without adverse effects is promising for chronic non cancer pain and pain relief in the united states.