Cannabinoids, Immune Cell Apoptosis/Suppression | cannabisMD

Cannabinoids, Immune Cell Apoptosis and Immunosuppression

Immune Cell Apoptosis and Immunosuppression and influence of cannabinoids

Image Credit: Andrii Vodolazhskyi on Shutterstock

Cannabinoids are present in the cannabis plant (cannabis sativa) and is said to have a potential as an anti inflammatory agent. It’s constituents include cannabidiol (CBD) and tetrahydrocannabinol (THC), which is responsible for the psychoactive effect and the reason why its illegal in most countries. The endocannabinoid system in the body bares cannabinoid receptors and these allow cannabinoids to work in the body. The 90’s saw the discovery of cannabinoid receptors (CB1 and CB2) and this has led to extensive study in the field of cannabinoids. This paper will look at the mechanisms in which the cannabinoid receptor 2 plays host to apoptosis through the immunosuppression by cannabinoids and how this leads to a range of benefits for the immune system.

Here is the full scientific article if you wish to download it.

Cannabinoids can stimulate the appetite
Cannabinoids have been approved in only some countries because it has been shown to help cancer patients with their chemotherapy treatment. Cannabinoids can reduce nausea and vomiting. In a clinical trial by Guzman, cannabinoids have been shown to inhibit pain and to stimulate appetite.

Cannabinoids have an anti inflammatory effect
Cannabinoids can also have a therapeutic potential because of its anti inflammation properties. When the dose of cannabis induction is right, apoptosis can occur in immune cells and this results in a reduction of inflammation in host cells. In patients with diseases such as MS, arthritis or lupus, the activated immune cells can be targeted via cannabinoid 2 receptor agonists and result in a decrease in inflammation. There will be no physcoactive side effects resulting from targeting the CB2 receptor and this is key in the potential to provide therapeutics against autoimmune diseases.

More research is needed in human trials to fully evaluate the mechanisms for immunosuppression and how cannabinoids can be used as a therapeutic for inflammatory diseases. Cannabinoids may actually worsen breast cancers that do not have cannabinoid.

Jonathan Neilly

Registered with the British Psychological Society, breaking the taboo on mental health issues is one of the driving forces in Jonathan's life. His background in biomedicine gives him additional understanding of the factors that work together to influence the human condition.

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