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Cannabinoids are a group of chemicals derived from the marijuana plant (cannabis sativa). There are over 100 different chemical comounds found in the cannabis plant. Cannabidiol (CBD) is one of these chemicals and it is said to have anti inflammatory effects on animal cells. Tetrahydrocannabinol (THC) is another one of these chemicals that produces a psychoactive effect in the brains of the animals who have taken it. Both THC and CBD are so far, the only two that are beleived to have medical benefits. Cannabinoid receptors are located in the endocannabinoid system and allow cannabinoids to bind and work in the body. This paper will look at how cannabinoids can influence cannabinoids cell proliferation, death and morphology of human glioblastoma multiforme cell lines and in human glial cultures, the average cells from where glioblastoma tumor growth comes from.
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THC decreases cell proliferation
Average tissue toxicity restricts the effectiveness of recent treatment modalities for glioblastoma multiforme. The part that plant derived cannabinoid agonist plays (THC, and a highly concentrated synthetic cannabinoid agonist, WIN 55,212- 2, were paralleled using time lapse microscopy. It was found that THC reduces cell proliferation and expands apoptosis of human glioblastoma multiforme cells at a greater rate than WIN 55,212-2. THC was also stronger at inducing the proliferation of glioblastoma multiforme cells when paralleled with WIN 55,212-2.
THC increases cell death because of cannabinoid receptor activation
The result of inducing THC and WIN 55,212-2 into glioblastoma multiforme cells of animal models was that of cannabinoid receptor activation. Similar doses of THC, that massively inhibits proliferation and betters apoptosis of recurrent glioblastoma multiforme cells, have no big effect on human main glial cultures. Results of effectiveness with WIN 55,212-2 was seen, however the selectivity was less profound, and the synthetic cannabinoid increased destruction of average cell structure compared to the THC.