Cannabinoids | Treatment Potential for Epilepsy | cannabisMD

Cannabinoids and Their Potential for The Treatment of Epilepsy

Cannabinoids and their Role in the Treatment of Epilepsy

The Cochrane Collaboration

Cannabis, also known as marijuana, is used by 4.5% of the world’s population and only recently it has been extensively studied due to its anti inflammatory properties. Cannabidiol (CBD) and tetrahydrocannabinol (THC) are the main constituents of the cannabis plant. The group that represents these constituents are called cannabinoids. CBD and THC could have a potential in reducing the amount of seizures an epileptic has. Clinical trials have proven that THC has weak properties in reducing seizures. This paper will look at the ingestion of cannabis extracts in humans and how it can be used in the goal of seizure freedom in people with the epilepsy syndrome.

Here is the full scientific article if you wish to download it.

Main Points

  • CBD can reduce the frequency of seizures
  • CBD can reduce seizures without side effects

CBD can reduce the frequency of seizures

No previous studies have had the same outcome of this review, in that when patients are administered with medical marijuana, freedom from seizures can be achieved up to 12 months. One of the weaknesses of this review is that only 4 previous studies were used in its design and that other crucial studies were left out. In a previous study by Mechoulam, 9 patients with epilepsy were treated with 200 mg of CBD and there usual medication. 2 of 4 patients were free from seizure for 3 months during treatments and the other 5 with placebo had no improvement in the seizure frequency and thus no improvement in the quality of life in people with epilepsy.

CBD can reduce seizures without side effects

In 4 studies used to design this review, there were no side effects in any of the patients administered with CBD, except for one study by Ames which reported mild drowsiness in one patient. In Mechoulams study, no toxic effects were found in patients administered with CBD. In a controlled trial by Trembly, 12 patients were treated with 300 mg of CBD over 12 months. This study resulted in reduction in seizure frequency in some of the patients with absolutely no side effects. Also, in a study by Consroe, 10 patients were treated with CBD however seizure frequency wasn’t affected but the patients did not have any further side effects.

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