The cannabis plant (cannabis sativa) is one of the most widely used drugs in the world and is usually smoked by the people who use it. Cannabinoids are a group of chemicals in the marijuana plant and its constituents include tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD is the non psychoactive part of cannabis and it is suggested that it is an antineoplastic agent against tumor cells. The mechanism in how CBD mediates these actions are not quite known yet. This paper will look at if CBD can induce cell death in breast cancer cells.
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CBD may cause death in breast cancer cells
In this clinical study, it was illustrated that CBD can induce cell death in breast cancer cells. This is demonstrated by the cannabinoids activation the vanilloid receptor. This receptor is located within the endocannabinoid system and allows cannabinoids to carry out their anti inflammatory work. Electron microscopy has revealed that autophagy and apoptosis can co exist in cells, and this was discovered through the western blot analysis method. CBD was seen to increase the generation of reactive oxygen species (ROS), and ROS inhibition stopped the introducing of apoptosis and autophagy. The study has suggested that there is complex interplay between apoptosis and autophagy in breast cancer cells that are treated with CBD. This highlights the potential use of CBD as an antineoplastic agent to treat breast cancer.
CBD can be a therapeutic for breast cancer patients
Medical marijuana has been seen to be a therapeutic agent because of its anti inflammation properties. The dose of cannabis needs to be perfect so that apoptosis can occur in immune cells and this concludes with a decrease of inflammation in host cells. In patients with diseases such as breast cancer, immune cells that are activated can be pinpointed by way of cannabinoid 2 receptor agonists. CBD has no psychoactive side effects and this is key in the potential to provide therapeutics against different types of cancer, such as prostate cancer, spreading in the body.