There have been numerous studies performed on animal subjects to test for potential health benefits in the case of using cannabis to tackle diabetes. Research that has been conducted has implied that the use of cannabis may help with stabilising blood sugars, preventing nerve inflammation, lowering blood pressure over time, keeping blood vessels opened and improving circulation.
After studies executed on mice, researchers provided evidence that the mice and their metabolism increased which in turn, lowered levels of cholesterol in the blood and/or fat within the liver.
This paper will look at how cannabinoids can offer salvation from those suffering at the hands of neuropathic pain in rat models of type 1 and type 2 diabetes.
Here is the full scientific article if you wish to download it.
This study compares the impact of the nonspecific cannabinoid agonist WIN 55,212-2 (WIN) in Zucker Diabetic Fatty (ZDF) rats (type 2 diabetes) and in STZ-injected Wistar rats (type 1 diabetes). WIN (or its vehicle) was either systemically administered at a non-psychoactive dose or locally injected. Selective CB1 and CB2 cannabinoid antagonists were used to describe WIN antineuropathic impacts.
Both type 1 and type 2 diabetic rats showed mechanical allodynia but not thermal hyperalgesia. WIN alleviated mechanical allodynia in both models of diabetes. In STZ-treated rats, both cannabinoid receptors were included, whereas in ZDF rats, WIN impacts seemed to mainly involve the triggering of CB1 receptors. Greater doses of WIN were needed to massively alleviate mechanical allodynia upon intraplantar administration in ZDF vs. STZ-injected rats.
Cannabinoids, acting on systemic and/or peripheral receptors, may just as a new therapeutic alternative for symptom management in painful neuropathy associated with both type 1 and type 2 diabetes. Additionally, these conclusions highlight the need for appropriate selection of diabetic experimental models because the results from studies in STZ-induced diabetic rodents might not be useful in all diabetic situations.