Cannabinoids and their Potential Medical Implications | cannabisMD

Cannabinoids and their Potential Medical Implications

Cannabinoids and their Potential Medical Implications; Taylor and Francis

Taylor and Francis

Cannabinoids: Medical implications

A cannabinoid is one of a collection of complex chemical compounds that operates on cannabinoid receptors in cells that fluxuates neurotransmitter release in the brain. Cannabinoids for these receptors include the endocannabinoids, that are made naturally in the body by animals, the phytocannabinoids in cannabis and some other plants, and synthetic cannabinoids. The main cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive chemical in cannabis. Cannabidiol (CBD) is another main constituent of the plant and produces a non psychotic effect. This paper will review cannabis and the administrative consequences that comes with it.

Main Points

  • Cannabinoids have a therapeutic potential
  • Endocannabinoid system may hold the answers into alleviating adverse events

Cannabinoids have a therapeutic potential

Herbal cannabis has been smoked for millennia for medicinal reasons. It has been used to treat disorders like chronic cancer, neuropathic pain and certain symptoms of multiple sclerosis, bare important reports supporting cannabinoid efficacy. While herbal cannabis has not met extensive FDA standards for medicinal approval, selective well-described cannabinoids have met those conditions. Where medical cannabis is legal, people normally see a physician who ‘‘certifies’’ that a benefit might conclude. Physicians must seek detrimental patient selection criteria such as unsuccessful standard medical treatment for a destructive medical syndrome. Medical cannabis patients must be learned about possible side effects, such as acute impairment of the brain, coordination and judgment, and potential chronic impacts, such as cannabis use syndrome, cognitive destruction, and chronic bronchitis. More so, social dysfunction may conclude at work/school, and there is more of a potential of motor vehicle accidents. Novel ways to modulate the endocannabinoid system are being investigated to maximize benefits of cannabinoid therapy and lessen potential bad impacts.

Endocannabinoid system may hold the answers into alleviating adverse events

The medical syndromes with the current best report that supports a benefit for cannabinoid use are the following: ‘multiple sclerosis patient-reported symptoms of muscle stiffness (nabiximols, nabilone, dronabinol, and oral cannabis extract), multiple sclerosis central pain or painful spasms (nabiximols, nabilone, dronabinol, and oral cannabis extract), multiple sclerosis bladder frequency (nabiximols), and chronic cancer pain/neuropathic pain (nabiximols and smoked THC)’. The standard human endocannabinoid system is detrimental in the understanding of such problems as normal physiology, cannabis use syndrome, and the advancement of prescriptions that may act as agonists or antagonists to CB1 and CB2. By getting to know the endocannabinoid system, there may lie a potential to increase the beneficial impacts of cannabinoid-related prescription, while decreasing the bad impacts.

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