Cannabinoids and their Function in the Immune System | cannabisMD

Cannabinoids and their Function in the Immune System

Cannabinoids and their Function in the Immune System; Research Gate

Research Gate

Cannabinoids and the immune system

A cannabinoid is one of a great collection of complex chemical compounds that naturally occur in the body and operates on major cannabinoid receptors in cells that mediates neurotransmitter release in the brain. Cannabis sativa is the marijuana plant in which cannabinoids are derived from. Cannabinoids for these receptors include the endocannabinoid system, that are produced in the body by animals, the plant cannabinoids in cannabis and some other plants, and synthetic cannabinoids. The main cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive chemical in cannabis. Cannabidiol (CBD) is another main constituent of the plant and produces a non psychotic effect. This paper will evaluate cannabinoids role in the immune system.

Main Points

  • Cannabinoid system has a role in regulating immune system
  • Cannabinoids have anti inflammatory effect

Cannabinoid system has a role in regulating immune system

The impact of cannabimimetic drugs on the ability of immune white blood cells in bone marrow such as T and B lymphocytes, natural killer cells and macrophages has been massively looked at over the last few years using human and animal paradigms including whole animal experiments as well as tissue culture networks. From this study, it can be said that these agents have low key yet complicated impacts on immune cell ability and that some of the agent activity is controlled by cannabinoid receptors conveyed on the numerous immune cell subtypes. However, the actual role of the endogenous cannabinoid network of receptors and their corresponding cannabinoids in animal health and disease is still not clear and needs a lot of extra light shed on it’s method. More research will describe the precise structure and function of the putative immunocannabinoid system, the possible therapeutic application of these drugs in chronic disorders such as an acquired immune deficiency condition, nausea and vomiting, and multiple sclerosis, the impacts of these drugs on tumour development and induction of cell death, and the potential anti-inflammatory and proinflammatory abilities of cannabimimetic chemicals. It is likely that the cannabinoid system, along with other neuroimmune networks, has a low key but massive role in the mediation of immunity and that this job can actually be exploited in the controlling of human disease.

Cannabinoids have anti inflammatory effect

A number of factors indicate that increased application of cannabis and cannabinoids in the United States and Canada over the coming couple of decades. Although a lot has been discovered regarding the chemistry and biology of these drugs, much more needs to be found in all areas of cannabinoid biology, including impacts on immune function. The immune network is extremely complicated, consisting of a number of organs, cells, tissues and soluble aspects working with each other to make a plethora of impacts. This complication gives many reasons for cannabinoids to change immune function, and over the past decade or so, many of these reasons have been evaluated. From a number of studies, cannabinoids have been displayed to change innate immunity. However, from these studies, it cannot be said that cannabis smoking is the reason for serious immunodeficiency in humans. What can be said is that these agents have the ability to change immune function through both receptor- and non-receptor-regulated actions. Clearly, additional research is needed to evaluate the actual structure and function of the putative immunocannabinoid network; the possible analgesic application of these agents in chronic infectious diseases such as HIV AIDS, rheumatoid arthritis and multiple sclerosis; the immune response of these drugs on tumour development and induction of cell death; and the potential anti-inflammatory and proinflammatory abilities of cannabimimetic chemicals. It is likely that the cannabinoid system, along with other neuroimmune networks, has a low key but massive role.

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