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Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry / seborrheic skin and acne treatment
Marijuana is a derived-product from the plant C. sativa. Cannabinoids are found in this cannabis plant and it holds the chemical tetrahydrocannabinol (THC) which is the psychoactive part of cannabis that gives you a ‘stoned feeling’. Cannabidiol (CBD) is the non psychoactive chemical of cannabis and it is said to have anti inflammatory properties. CBD’s that produce oil, such as hemp oil, are currently popular at the minute because of their ability to treat anti inflammation in the skin. This paper will look at how a range of CBD’s could possibly treat seborrheic skin and acne.
Acne is a common skin disease that inflames a person’s sebaceous glands and it has previously been shown that nonpsychoactive phytocannabinoid cannabidiol (CBD) exerts strange anti-acne effects by normalizing sebaceous lipid production, reducing proliferation and alleviating inflammation in human SZ95 sebocytes.
This paper also describes how other cannabinoids can have anti-acne effects. The other cannabinoids include cannabichromene [CBC], cannabidivarin [CBDV], cannabigerol [CBG], cannabigerovarin [CBGV] and tetrahydrocannabivarin [THCV]. It was seen that these cannabinoids only altered the viability of sebocytes at small doses, however at high doses, malignant skin cells died off. Interestingly, basal sebaceous lipid synthesis was differentially modulated by the substances: CBC and THCV were shown to suppress acne whereas CBG and CBGV only suppressed it a little. Importantly, CBC, CBDV and THCV significantly reduced acne symptoms.
This paper suggests that CBG and CBGV can be used to treat dry skin, however CBC, CBDV and THCV can be used as anti acne agents. Overall CBD oil products have excellent anti inflammatory properties and are safe to use on the skin to treat acne with no side effects.Olah_et_al_EXD_2016_ACCEPTED_version.compressed