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Cannabinoids are a group of chemicals derived from the cannabis plant (cannabis sativa). Cannabidiol (CBD) is one of these chemicals and research has shown that it has anti inflammatory properties to heal animals with nervous system disorders. Tetrahydrocannabinol (THC) is another one of these compounds that wields a psychoactive effect in animals. Cannabinoid receptors (CB1 and CB2) are found in the endogenous cannabinoid system and allow cannabinoids to bind and do their job in the body. This paper will take a look at synthetic cannabinoid Nabilone and how it can treat people with chronic non cancer pain.
Here is the full scientific article if you wish to download it.
Naboline may be useful in pain management
Cannabis products have been used alot in the past for chronic pain and is gaining renewed industry interest. Nabilone is a synthetic cannabinoid made in Canada for the treatment of serious nausea and vomiting related to cancer chemotherapy. Scientists have used nabilone for the treatment of chronic noncancer pain since the 90’s. This paper describes the clinical experience of 20 adults with chronic noncancer pain who had been given nabilone and followed up for a year and a half. Before nabilone treatment, the people in the study had used different kinds of therapies, including 11 who had taken cannabis. Fifteen patients said that there pain was majorly alleviated after taking nabilone. Positive impacts on sleep and nausea were the important motives for continuing nabolin usage. Intolerable side effects were experienced in three people. These included palpitations, urinary retention, dry mouth. Nabilone might potentially be good for pain management and should be further studied in randomized controlled trials.
Naboline causes no serious side effects
No severe side effects were reported by these people in the study. Three patients could not withstand the side effects of nabilone and stopped using the drug within the very first week. One patient said palpitations, one said dry mouth, and one said increased urinary retention for the reasons to stop using nabilone. Other adverse effects that were experienced were dry mouth, headaches, nausea and vomiting in the very first week of nabilone use. Other side effects included apathy, puffy lips, red cheeks, fatigue, palpitations, decreased clarity, decreased concentration, decreased focus, dizziness, drowsiness, transient deformity of left side of face in the first week, depression, and forgetfulness.