Cannabinoids are a group of chemicals that arise from the cannabis plant (cannabis sativa). Cannabidiol (CBD) is one of these compounds and studies have proved it has anti inflammatory effects when induced in animal cells. Tetrahydrocannabinol (THC) is another one of these chemicals that gives off a psychotropic effect in animals. Cannabinoid receptors (CB1 and CB2) are found in the endocannabinoid system and allow cannabinoids to bind and work in the body. This paper will review current knowledge on the antitumor ability of cannabinoids in breast cancer in humans, and this suggests that drugs made from cannabinoids can be used for the treatment of breast tumors.
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Cannabinoids have anti tumor properties
There is plenty of evidence demonstrating that cannabinoids possess anti-tumor properties in preclinical models of breast cancer. These results are shown from cell culture systems and also in animal models. This anti-tumor ability is made by the stopping of inhibitors of cancer and the chemicals are not only efficient but very safe with no side effects. More clinical trials should take place to widen knowledge about certain problems to be solved. For instance, although breast cancer seems to react to cannabinoids, it would be effective to describe what would be the best patient population for therapeutic medicinal cannabis. The best preclinical evidence points to HER2-positive and triple-negative tumors.
Cannabinoid selection Important in breast cancer patient administration
Another dire question is what cannabinoids are the most effective to be tested in people with breast cancer cells. This study illustrates that the best possible way to do this would be adding to the normal chemotherapy with a mixture of a cannabinoid agonist targeting CB1 or CB2 receptors and CBD. This mixture would have be very beneficial as two cannabinoid compounds acting through estranged mechanisms of action would produce a paralleled anti-tumor effect. CBD in this mixture would truly reduce the adverse effects of cannabinoids.