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Cannabinoids are a collection of over 100 chemicals that are derived from the cannabis plant (cannabis sativa). Cannabidiol (CBD) is one of these chemicals and research has said it has anti-inflammatory effects when induced on animal cells, without unwanted psychoactive side effects. Tetrahydrocannabinol (THC) is another one of these chemicals that gives off a psychotropic effect in animals brains. Endogenous cannabinoid receptors (CB1 and CB2) are found in the endocannabinoid system and allow cannabinoids to bind and work in the body. Understanding of the endocannabinoid system has led to THC being a primary activator of the CB 1 receptor. This paper will look at how cannabinoids can have an effect in preclinical models of Tourettes.
Here is the full scientific article if you wish to download it.
Recently, the treatment of Tourette’s syndrome hasn’t been up to par. This has lead to the growing interest in current therapeutic treatment methods. Anecdotal studies have said that cannabis ingestion may better not just tics, but also behavioral disorders in Tourettes. In this paper,12 people who had Tourettes were administered doses of THC, the main psychoactive component of marijuana, which led to these patients having fewer tic episodes.
In this experiment, the 12 patients did not receive any unwarranted side effects or neuropsychological disturbances when taking the THC. This has lead to the belief that if modern pharmaceutical companies can not come up with an answer for tic reduction, THC could potentially do a good job in just that. In marijuana, it remains a mystery if natural or synthetic cannabinoid receptors agonists, that mess with the inactivation of endocannabinoids, can actually have the right properties to reduce Tourette related syndromes.