Cannabinoids and the Reduction of Skin Tumour Growth | cannabisMD

Cannabinoids and the Reduction of Skin Tumour Growth

Cannabinoids and the Reduction of Skin Tumour Growth; JCI

JCI

Cannabinoids thrive in the marijuana plant and are seen to be good at pain mediation from symptoms such as anxiety and depression. A cannabinoid is one of a massive group of complex chemical compounds that work endogenously and binds to primary cannabinoid receptors 1 and 2. Cannabinoids for these receptors are found in the endocannabinoid network where plant cannabinoids, synthetic cannabinoids and the bodies own supply of cannabinoids. The major endogenous cannabinoid is the plant cannabinoid tetrahydrocannabinol (THC), the focal psychotropic compound in marijuana. Cannabidiol (CBD) is the other major compound of the plant and gives off a non psychotic effect. Cannabinoids have a therapeutic possibility without a shadow of a doubt, however they are not quite fully put into light, to treat a wide gutter of human disorders. This paper will look at how cannabinoids can be used to treat skin tumor growth and angiogenesis.

Here is the full scientific article if you wish to download it.

Main Points

  • Cannabinoids may have a therapeutic ability
  • Cannabinoids have an anti inflammatory potential

Cannabinoids may have a therapeutic ability

Nonmelanoma skin cancer is one of the more known malignancies in humans. Numerous therapeutic plans for the curing of these tumors are now being looked into. Given the growth-inducing impacts of cannabinoids on gliomas and the wide tissue distribution of the two different groups of cannabinoid receptors 1 and 2, researchers here have looked into possible application of these compounds in anti–skin tumor treatment. Researchers display here that the cannabinoid receptors 1 and 2 are communicated in standard skin and skin tumors of mice and humans. In cell culture trials pharmacological triggering of cannabinoid receptors induced the cell death of tumorigenic epidermal cells, whereas the ability of non transformed epidermal cells came through the woodwork unharmed. Local dosing of the mixed cannabinoid receptor 1 and 2 agonist WIN-55,212-2 or the specific cannabinoid 2 agonist JWH-133 induced a considerable development inhibition of destructive tumors made up by inoculation of epidermal tumor cells into naked mice. Cannabinoid-treated tumors displayed an increased amount of dying cells. This was side kicked by the destroying of tumor vascularization, as deemed by modulated blood vessel morphology and reduced expression of proangiogenic conditions. These conclusions lend a hand to a fresh therapeutic approach for the treatment of skin tumors.

Cannabinoids have an anti inflammatory potential

Nonmelanoma skin cancer is one of the most known malignancies in humans. Different types of plans are currently being looked into as therapies for the treatment of these tumors, including cryotherapy, topical chemotherapeutic drugs such as 5-fluorouracil, and photodynamics, the success of which is intervened by preventions such as the lack of penetration of molecules into the epidermis and the hardship of receiving an open door to the whole tumor. The current data suggests that local cannabinoid dosing may constitute a different therapeutic method for the treatment of nonmelanoma skin cancer. Of further therapeutic intrigue, researchers here display that epidermis cells communicate functional cannabinoid 2 receptors. The synergy between cannabinoid 1 and 2 receptors in allowing skin tumor cell death reported here is no doubt interesting because it is not seen in the case of cannabinoid-induced glioma cell death. In any event, the current evaluation, together with the problem of cannabinoid 1 and 2 like receptors in the regulation of peripheral pain and inflammation, reveals the attractive possibility of finding cannabinoid-based therapeutic blueprints for disorders of the skin and other tissues devoid of non wanted cannabinoid receptor 1 controlled psychotropic adverse events.

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