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Cannabinoids are a group of chemicals located in the cannabis plant (cannabis sativa). These chemicals include tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the psychoactive part of cannabis while CBD is quite the opposite, and is said to have anti inflammatory properties. The cannabinoid receptors (CB1 and CB2) are located within the bodies endocannabinoid system and they allow these chemicals to work. This paper will look at how the endocannabinoid system modulates pancreatic inflammation, thus a realising the therapeutic value of cannabinoids.
Here is the full scientific article if you wish to download it.
Cannabinoids may reduce inflammation in acute pancreatitis
Endocannabinoid levels of CB1 and CB2 were measured in the pancreas from mice and patients with pancreatitis. Histological examinations took place to quantify inflammation and the pain was assessed as abdominal hypersensitivity to emphasized Frey stimuli. The behaviour of the mice and patients were analysed to see if the cannabinoids had any central side effects. Patients baring acute pancreatitis displayed an increase in cannabinoid receptors and cannabinoids in the pancreas. A synthetic cannabinoid, HU210, seemed to reduce the abdominal pain and inflammation in mice without producing any unwarranted side effects. CB1 and CB2 receptors agonists successfully reversed HU210 antinociception.
Cannabinoids may have a therapeutic value
In humans subjects, acute pancreatitis is related with up-regulation of ligands, and also the increase in receptors in the endocannabinoid system in the pancreatic region. The results of this study illustrate the potential for cannabinoids to be therapeutic in humans and mice, and to reduce the pain and inflammation that is associated with acute pancreatitis. Cannabinoids have little known adverse effects and this makes them a top player for pain management. More studies will need to be conducted in order to test cannabinoids full potential in humans, however the result of this study is promising.