Cannabinoids are found in the cannabis plant and its main constituents are cannabidiol (CBD) and tetrehyrocannabidoil (THC). Cannabinoids are said to have anti inflammatory effects in animal cells. THC is the main constituent responsible for cannabis’ psychoactive effects and it is why cannabis has gotten a bad reputation in the past. This paper will look at the effects cannabis and how they can potentially alter HIV RNA levels by two particular mechanisms. One being immune modulation and the other being cannabinoid-protease inhibitor interactions. The objectives of this study was to determine the short term side effects of smoking marijuana in HIV patients.
Here is the full scientific article if you wish to download it.
Short Term Effects of Marijuana
67 patients with HIV were studied in San Francisco General Hospital. Patients were given 4 % THC marijuana cigarettes and a 2.5 mg dronabinol capsule 3 times a day before meals.
The results showed that smoked and oral cannabinoids were not unsafe to people with the HIV infection as it did not affect HIV RNA levels, CD4 and CD8 cell counts during the 21 day treatment study.
Another aim of this study was to get some valuable information on how medical marijuana can reverse the loss of appetite and stop weight loss. Previous studies have demonstrated dronabinol to be the main culprit in affecting the trend for weight gain in HIV treatment. This study shows that THC and CBD are increasing weight in patients due to appetite changes. However, the weight gained by the medical cannabis induced patients were not in the desired lean body mass but in fat.
While the study is promising, it’s crucial to note that cannabinoids need a lot more scientific attention. If you wish to use medical cannabis or CBD, make sure you consult your doctor.